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High-dose verapamil + trandolapril-induced thrombotic microangiopathy. | LitMetric

High-dose verapamil + trandolapril-induced thrombotic microangiopathy.

Haematologia (Budap)

Department of Emergency Medicine, Faculty of Medicine, Cukurova University, Adana, Turkey.

Published: November 2003

Thrombotic microangiopathy (TMA) is a syndrome characterized by microangiopathic haemolytic anaemia, thrombocytopenia, and several variable signs of organ damage due to the platelet thrombi in the microcirculation. This article reports a case with TMA which developed after ingestion of a high-dose combination of verapamil and trandolapril. To the authors' knowledge, no prior cases of TMA induced by trandolapril (an angiotensin-converting enzyme inhibitor) and verapamil (a calcium channel blocker) have been reported in the literature.

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Source
http://dx.doi.org/10.1163/15685590260461101DOI Listing

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