AI Article Synopsis

Article Abstract

Familial Mediterranean fever (FMF) is characterized by an autosomal inheritance pattern, Mediterranean ancestry, and history of recurrent fever. We present a 30-year-old Turkish man with FMF and accompanying seronegative spondyloarthropathy. His diagnose depended on the clinical course of his disease: recurrent fever accompanied by abdominal pain attacks together with a positive family history and his ethnic origin and sacroiliitis. We review the common manifestations of FMF and remind physicians that sacroiliac joint involvement must be kept in mind in presence of articular symptoms in a FMF patient.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00296-002-0239-2DOI Listing

Publication Analysis

Top Keywords

seronegative spondyloarthropathy
8
familial mediterranean
8
mediterranean fever
8
recurrent fever
8
spondyloarthropathy familial
4
fever
4
fever familial
4
fmf
4
fever fmf
4
fmf characterized
4

Similar Publications

Background: Total hip arthroplasty (THA) is a common surgical intervention for patients who have seronegative spondyloarthropathies (SpA). However, there is a paucity of literature addressing the outcomes of THA specifically in SpA patients. This study aimed to investigate both the short-term and long-term systemic and orthopaedic outcomes of THA in SpA patients as a whole, as well as within the individual subtypes of SpA.

View Article and Find Full Text PDF

Serum selenium, selenoprotein P and glutathione peroxidase 3 in rheumatoid, psoriatic, juvenile idiopathic arthritis, and osteoarthritis.

J Nutr Biochem

January 2025

MVZ Endokrinologikum Berlin am Gendarmenmarkt, Berlin, Germany; Charité Universitätsmedizin Berlin, Klinik für Rheumatologie und Klinische Immunologie, Berlin, Germany. Electronic address:

Article Synopsis
  • Selenoprotein P (SELENOP) and glutathione peroxidase 3 (GPx3) are vital for selenium transport and antioxidant activity in blood, with a focus on their roles in inflammatory rheumatic diseases like rheumatoid arthritis (RA), psoriatic arthritis (PsA), and juvenile idiopathic arthritis (JIA).
  • A study involving 272 patients found that both SELENOP and selenium levels were lower in patients with inflammatory rheumatic diseases compared to healthy controls, with particularly low GPx3 activity in JIA and PsA groups.
  • The findings suggest that selenoprotein deficiencies may contribute to disease severity, emphasizing the potential for personalized selenium supplementation to enhance selenoprotein production and improve
View Article and Find Full Text PDF

Background: Rheumatoid arthritis (RA) is an autoimmune disease with various subtypes. Among these, seronegative rheumatoid arthritis (SnRA), distinguished by its distinctive seronegative antibody phenotype, presents clinical diagnosis and treatment challenges. This study aims to juxtapose the immunological features of SnRA with seropositive rheumatoid arthritis (SpRA) to investigate potential mechanisms contributing to differences in antibody production.

View Article and Find Full Text PDF

Autoantibody mediated deficiency of IL-36-receptor antagonist in a subset of patients with psoriasis and psoriatic arthritis.

Immunol Lett

December 2024

José Carreras Center for Immuno- and Gene Therapy and Internal Medicine I, Saarland University Medical School, Homburg, Saar, Germany. Electronic address:

Objective: Psoriatic arthritis (PsA) is known as a seronegative form of spondylarthropathy. The interleukin-36 cytokine family may have a major role in disease pathogenesis and particularly the related cutaneous manifestations. In light of our recent observations on (transient) autoantibody phenotypes neutralizing endogenous anti-inflammatory receptor antagonists (progranulin, IL-1Ra) in different inflammatory conditions, we set out to investigate the potential role of such antibodies targeting IL-36 cytokine family members in PsA and psoriasis without arthritic manifestations (Pso).

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!