The efficiency of plasmapheresis versus routine methods of detoxification in the complex treatment was compared in 100 patients with acutely progressive pulmonary tuberculosis. After 2 and 4 months, plasmapheresis was found to arrest the intoxication syndrome in 56 and 100% of the patients, respectively. This treatment in these patients resulted in ceased bacterial isolation in 52% of the patients following 2 months and lung cavern closure in 36% of cases after 6 months. This ultimately reduced the time of hospital stay on the average of 2 months, its duration being not longer than 7-8 months.
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Neurosurg Rev
January 2025
Sorbonne Université, Groupe Hospitalo-Universitaire Pitié-Salpêtrière, Paris, France.
Vestibular schwannoma (VS) is a benign tumor that varies in size and presentation. Surgery is the preferred treatment for large or symptomatic VS. Facial nerve (FN) preservation is a priority because of its impact on well-being.
View Article and Find Full Text PDFArch Pharm Res
January 2025
College of Pharmacy, Keimyung University, Daegu, 42601, Republic of Korea.
Tumor microenvironment (TME) is composed of diverse cell types whose interactions, both direct and indirect, significantly influence tumorigenesis and therapeutic outcomes. Within TME, reactive oxygen species (ROS) are produced by various cells and exhibit a dual role: moderate ROS levels promote tumor initiation and progression, whereas excessive levels induce cancer cell death, influencing the efficacy of anticancer therapies. Inflammasomes, cytosolic multiprotein complexes, are pivotal in multiple stages of tumorigenesis and play a crucial role in establishing the inflammatory TME.
View Article and Find Full Text PDFMol Biol Rep
January 2025
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India.
Pancreatic cancer remains as global health challenge, ranking as the seventh leading cause of cancer-related deaths worldwide with high mortality rates and a low five-year survival rate. Despite advancements in conventional therapies, including surgery, chemotherapy, and radiation, the overall survival rates for pancreatic cancer patients have shown minimal improvement. Consequently, there is an urgent need for alternative therapeutic strategies.
View Article and Find Full Text PDFCell Mol Life Sci
January 2025
Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, 03722, Republic of Korea.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a chronic condition encompassing metabolic dysfunction-associated steatotic liver (MASL) and metabolic dysfunction-associated steatohepatitis (MASH), which can progress to fibrosis, cirrhosis, or hepatocellular carcinoma (HCC). The heterogeneous and complex nature of MASLD complicates optimal drug development. Ebastine, an antihistamine, exhibits antitumor activity in various types of cancer.
View Article and Find Full Text PDFEur Radiol
January 2025
Trauma Research Unit, Department of Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Introduction: Injury coding with the Abbreviated Injury Scale (AIS) is an important element for benchmarking, trauma registries and research.
Objective: To compare the severity of traumatic brain injury (TBI) coding derived from the AIS with or without the use of a standardised radiologic template.
Methods: A retrospective two-centre cohort study including patients aged ≥ 18 years with isolated TBI admitted to an intensive care between 2011 and 2016 was conducted.
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