This communication describes a self assembled porphyrin sphere. The globular macromolecular assembly contains 12 terminal porphyrins and has a molecular mass in excess of 15,000 g mol-1.
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Comparative Study of Functionalized Carbosilane Dendrimers for siRNA Delivery: Synthesis, Cytotoxicity, and Biophysical Properties.
ACS Omega
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Institute of Chemical Process Fundamentals Czech Academy of Sciences, Rozvojová 135, Prague 165 02, Czech Republic.
Efficient and safe carriers of genetic material are crucial for advancing gene therapy. Three new series of cationic dendritic nanocarriers based on a carbosilane scaffold, differentiated by peripheral modifications: saccharide (CS-glyco), amine (CS-N), and phosphonium dendrimers (CS-P) were designed for binding, protecting, and releasing polyanionic compounds like therapeutic siRNA. Besides introducing synthetic methodology, this study brings a unique direct interstructural comparison of 16 dendritic nanovector's characteristics, addressing a gap in typical research that focuses on uniform structural types.
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Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota 55905, United States.
Traditional polymer systems often rely on toxic initiators or catalysts for cross-linking, posing significant safety risks. For bone tissue engineering, another issue is that the scaffolds often take a longer time to degrade, inconsistent with bone formation pace. Here, we developed an enzyme-responsive biodegradable poly(propylene fumarate) (PPF) and polycaprolactone (PCL) polyphosphoester (PPE) dendrimer cross-linked utilizing click chemistry (EnzDeg-click-PFCLPE scaffold) for enhanced biocompatibility and degradation.
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J Mater Chem B
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National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
Microtia profoundly affects patients' appearance and psychological well-being. Tissue engineering ear cartilage scaffolds have emerged as the most promising solution for ear reconstruction. However, constructing tissue engineering ear cartilage scaffolds requires multiple passaging of chondrocytes, resulting in their dedifferentiation and loss of their special phenotypes and functions.
View Article and Find Full Text PDFAluminum-Free Borosilicate Glass Functionalized Hydrogels for Enhanced Dental Tissue Regeneration.
Materials (Basel)
November 2024
Laboratoire des Multimatériaux et Interfaces UMR CNRS 5615, Universite Claude Bernard Lyon 1, 6 rue Victor Grignard, 69622 Villeurbanne, France.
Hydrogels are promising scaffolds for tissue regeneration, and borosilicate glass particles have demonstrated potential in enhancing the biological behaviour of dental pulp cells. However, the specific morphological characteristics of dental lesions and the diverse requirements of dental tissues require biocompatible, bioactive, and shapeable scaffolds. This study aimed to evaluate the in vitro biological behaviour of human gingival fibroblasts (HGFs) in contact with an experimental aluminum-free borosilicate glass-functionalized hydrogel.
View Article and Find Full Text PDFSelf-Assembled Peptide Sheet-Mediated Multivalent Capture of Cells with Enhanced Tunability.
Chembiochem
December 2024
Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, Xiamen, 361005, China.
We report the creation of multivalent ligand surfaces for cell capture by conjugation of ligand-appended 2D peptide assemblies on an antifouling glass substrate. The sheet-like structures organize ligands into non-uniform, patchy patterns, enhancing multivalent cell targeting. A 155 % increase in captured cells was achieved compared to the presentation of the ligands on surfaces lacking the peptide sheets.
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