AI Article Synopsis
- Irofulven, an antitumor agent, reacts with zinc and acetic acid to produce new indene derivatives.
- The new derivatives (6, 7, 8, 10) and a known indene (9) were created in this reaction.
- These new compounds exhibit significantly lower toxicity to human leukemia cells (HL60) than irofulven itself.
Article Abstract
Reaction of antitumor agent irofulven (1) with zinc and acetic acid yielded several new indene derivatives (6, 7, 8, 10) as well as the known indene (9). These all have greatly reduced toxicity to human leukemia (HL60) cells compared to irofulven.
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| http://dx.doi.org/10.1021/np0204085 | DOI Listing |
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Reaction of irofulven with zinc and acid.
J Nat Prod
February 2003
Department of Chemistry, University of California, San Diego, La Jolla, California 92093-0506, USA.
Article Synopsis
- Irofulven, an antitumor agent, reacts with zinc and acetic acid to produce new indene derivatives.
- The new derivatives (6, 7, 8, 10) and a known indene (9) were created in this reaction.
- These new compounds exhibit significantly lower toxicity to human leukemia cells (HL60) than irofulven itself.
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