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Management of cardiac trauma and penetrating cardiac injuries with severe hemorrhagic shock: a 5-year experience.
J Trauma Inj
December 2024
Department of Cardiovascular and Thoracic Surgery, Tam Anh Hospital, Ho Chi Minh City, Vietnam.
Purpose: The diagnosis and management of cardiac trauma and penetrating cardiac injuries pose significant challenges in emergency settings due to the rapid onset of life-threatening complications. This paper presents a narrative review to better describe the etiology, presentation, and management of penetrating cardiac trauma, offering insights and experiences related to performing emergency surgery for such cases.
Methods: We compiled cases of traumatic cardiac rupture and penetrating cardiac injuries accompanied by severe hemorrhagic shock that necessitated emergency surgery.
Escalating Risks: Injury Patterns in Escalator-Related Trauma.
Cureus
November 2024
Trauma and Acute Care Surgery, Desert Regional Medical Center, Palm Springs, USA.
Falls from escalators, although infrequent, can result in a wide array of injuries, ranging from minor lacerations to fatal outcomes. This retrospective study aims to detail the treatment and outcomes of eight patients who sustained blunt-force trauma from escalator falls and received care at Desert Regional Medical Center in Palm Springs, California. Among these eight patients, seven required hospitalization, with three necessitating intensive care unit (ICU) admission, and two patients ultimately succumbing to their injuries.
View Article and Find Full Text PDFHemogram-Based Phenotypes of the Immune Response and Coagulopathy in Blunt Thoracic Trauma.
J Pers Med
December 2024
Department of Anesthesiology and Intensive Care II, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
: Blunt thoracic trauma possesses unique physiopathological traits due to the complex interaction of immune and coagulation systems in the lung tissue. Hemogram-based ratios such as neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR), neutrophil-to-lymphocyte × platelet (NLPR) ratios have been studied as proxies for immune dysregulation and survival in trauma. We hypothesized that blunt thoracic trauma patients exhibit distinct patterns of coagulation and inflammation abnormalities identifiable by the use of readily available hemogram-derived markers.
View Article and Find Full Text PDFPrevalence and Survival Rate of Trauma Patients who Underwent Resuscitative Thoracotomy in a Level One Trauma Center in Southern Iran.
Bull Emerg Trauma
January 2024
Trauma Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Objective: This study aimed to determine the prevalence and survival rate of trauma patients who underwent resuscitative thoracotomy (RT) in a level I trauma center in southern Iran.
Methods: This cross-sectional descriptive study conducted at Rajaee Hospital (Shiraz, Iran) from March 2018 to October 2022, included trauma patients who underwent RT surgery. Demographic information, vital signs at arrival, mechanism of injury, type of trauma, admission and discharge dates, length of hospital stay, blood transfusions, associated injuries, and clinical and laboratory parameters were evaluated.
Co-targeting of the thymic stromal lymphopoietin receptor to decrease immunotherapeutic resistance in CRLF2-rearranged Ph-like and Down syndrome acute lymphoblastic leukemia.
Leukemia
December 2024
Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
CRLF2 rearrangements occur in >50% of Ph-like and Down syndrome (DS)-associated B-acute lymphoblastic leukemia (ALL) and induce constitutive kinase signaling targetable by the JAK1/2 inhibitor ruxolitinib under current clinical investigation. While chimeric antigen receptor T cell (CART) immunotherapies have achieved remarkable remission rates in children with relapsed/refractory B-ALL, ~50% of CD19CART-treated patients relapse again, many with CD19 antigen loss. We previously reported preclinical activity of thymic stromal lymphopoietin receptor-targeted cellular immunotherapy (TSLPRCART) against CRLF2-overexpressing ALL as an alternative approach.
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