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Investigating the miRNA-mRNA interactome of human trabecular meshwork cells treated with TGF-β1 provides insights into the pathogenesis of pseudoexfoliation glaucoma.
PLoS One
January 2025
Biomedical Sciences Research Institute, Centre for Genomic Medicine, Ulster University, Coleraine, Northern Ireland, United Kingdom.
Pseudoexfoliation glaucoma is a severe form of secondary open angle glaucoma and is associated with activation of the TGF-β pathway by TGF-β1. MicroRNAs (miRNAs) are small non-coding RNA species that are involved in regulation of mRNA expression and translation. To investigate what glaucomatous changes occur in the trabecular meshwork and how these changes may be regulated by miRNAs, we performed a bioinformatics analysis resulting in a miRNA-mRNA interactome.
View Article and Find Full Text PDFAssessing blood metal levels in house sparrows (Passer domesticus) across urban and rural habitats in Meknes.
Environ Sci Pollut Res Int
January 2025
Natural Resources Management and Development Team, Environment and Health Laboratory, Department of Biology, Faculty of Sciences, Moulay Ismaïl University, Zitoune, B.P.11201, Meknes, Morocco.
This study investigates the concentration of heavy metals lead (Pb), cadmium (Cd), and zinc (Zn) in the blood of house sparrows (Passer domesticus) across various urban habitats in Meknes, Morocco. Fifty adult sparrows were captured from five distinct sites, including industrial, high-traffic, and rural areas. Blood samples were specifically analyzed for Pb, Cd, and Zn using Inductively Coupled Plasma Atomic Emission Spectroscopy (ICP-AES).
View Article and Find Full Text PDFWeb-Based Exercise and Nutrition Intervention to Improve Leg Muscle Strength and Physical Functioning in Older Adults: Pre-Post Pilot Study.
JMIR Form Res
January 2025
Division of Human Nutrition and Health, Wageningen University & Research, Stippeneng 4, PO Box 17, Wageningen, 6700 AA, Netherlands.
Background: The lifestyle intervention ProMuscle, which combines resistance exercise and an increased protein intake, was effective in improving muscle strength, muscle mass, and physical functioning in older adults. However, due to a growing shortage of health care professionals, the rapidly growing aging population cannot be personally guided in the future. Therefore, Uni2Move, a scalable web-based variant of ProMuscle, was designed to reach larger groups of older adults without putting additional burden on health care professionals.
View Article and Find Full Text PDFMicrobiome characterization of two fresh pork cuts during production in a pork fabrication facility.
Microbiol Spectr
January 2025
Department of Veterinary Population Medicine, University of Minnesota, St. Paul, Minnesota, USA.
The goal of this study was to characterize the microbial profile of two different fresh pork cuts, bootjack (BJ) trim and tenderloin (TL), through a 16S rRNA sequencing workflow developed specifically for investigating low-biomass fresh meat within a commercial production schedule. Additionally, this study aimed to determine a baseline prevalence and enumeration profile across these two fresh pork cuts. Results showed that microbiome diversity was different between the BJ and TL, and also differed significantly by processing date.
View Article and Find Full Text PDFInvestigating BLS instructors' ability to evaluate CPR performance: focus on compression depth, rate, and recoil.
BMC Emerg Med
January 2025
Department of Emergency Medicine, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, No.138, Sheng Li Road, Tainan city, 704, Taiwan.
Background: Out-of-hospital cardiac arrest (OHCA) presents significant challenges with low survival rates, emphasizing the need for effective bystander CPR training. In Basic Life Support (BLS) training, the role of instructors is pivotal as they assess and correct learners' cardiopulmonary resuscitation (CPR) techniques to ensure proficiency in life-saving skills. This study evaluates the concordance between CPR quality assessments by Basic Life Support (BLS) instructors and those determined through Quantitative CPR (QCPR) devices, utilizing data from BLS courses conducted at National Cheng Kung University Hospital from October 2017 to April 2018.
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