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Iodine-131 radioembolization boosts the immune activation enhanced by icaritin/resiquimod in hepatocellular carcinoma.
J Control Release
December 2024
Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Center for Biomedical Imaging, Fudan University, Shanghai 200032, China; Shanghai Engineering Research Center of Molecular Imaging Probes, Shanghai 200032, China; Key Laboratory of Nuclear Physics and Ion-beam Application (MOE), Fudan University, Shanghai 200433, China. Electronic address:
Transarterial radioembolization (TARE) is a recommended locoregional strategy for intermediate hepatocellular carcinoma (HCC), whereas, the effect is insufficient to reverse the immunosuppression tumor microenvironment, and the overall benefits for patients remain to be improved. In this study, a multifunctional microsphere (MS) I-ICT/R848-MS is developed to propose an approach combined with TARE, icaritin (ICT) and immune modulator resiquimod (R848). ICT and iodine-131 (I) radiation can induce immunogenic cell death, which, in combination with R848, will boost dendritic cell (DC) maturation.
View Article and Find Full Text PDFRadioactive Iodine Treatment for Thyroid Cancer Complicated by Lacrimal Sac Retention of Iodine.
JCEM Case Rep
January 2025
Division of Endocrinology, Medstar Georgetown University Hospital, Washington, DC 20007, USA.
Patients with intermediate-risk thyroid cancers may undergo treatment with radioactive iodine-131 (I-131). They often undergo a pretreatment diagnostic iodine scan that typically shows areas of physiological uptake in the stomach, bladder, parotid glands as well as thyroid-remnant uptake and sites of metastatic disease. A 48-year-old woman with intermediate-risk papillary thyroid cancer with metastases to lateral compartment lymph nodes was found to have increased retention of iodine in the medial portion of her left orbit on the diagnostic scan.
View Article and Find Full Text PDFIodine transfer to dairy cow's milk: A revised biokinetic model.
J Hazard Mater
December 2024
Faculty of Biosciences, Norwegian University of Life Sciences, PO Box 5003, Ås N-1432, Norway.
A new biokinetic model for iodine in dairy cows was developed utilizing data from a 4 × 4 factorial feeding experiment with rumen-cannulated cows that were fed rapeseed cake containing substances known to influence iodine metabolism, and soybean meal without such effects. I was administered both intravenously and intra-ruminally to document metabolism pathways. The new model included compartments such as saliva and thyroid gland, often ignored in other models, and in contrast to previously available biokinetic models, it fitted well to our experimental data.
View Article and Find Full Text PDFDirect Labeling of Gold Nanoparticles with Iodine-131 for Tumor Radionuclide Therapy.
Int J Nanomedicine
November 2024
Department of Nuclear Medicine, Northern Jiangsu People's Hospital, Clinical Medical College, Yangzhou University, Yangzhou, 225001, People's Republic of China.
Article Synopsis
- Gold nanoparticles (Au NPs) can be easily labeled with radioactive iodine, making them promising tools for tumor treatment and diagnosis in cancer therapy.
- This study evaluated the stability and effectiveness of iodine-adsorbed Au NPs in targeting tumors, using various conditions to analyze their performance.
- The results indicate that these iodine-adsorbed Au NPs are stable, effective in inhibiting tumor cells, and show therapeutic potential when injected into tumors in living subjects.
Responsive and traceless assembly of iron nanoparticles and I labeled radiopharmaceuticals for ferroptosis enhanced radio-immunotherapy.
Biomaterials
February 2025
State Key Laboratory of Natural Medicines, Key Laboratory of Drug Quality Control and Pharmacovigilance, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. Electronic address:
Ferroptosis is an iron-dependent form of programmed cell death with the potential to reverse traditional cancer therapy resistance. The combination of ferroptosis with chemotherapy, photodynamic therapy and X-ray therapy has demonstrated remarkably improved therapeutic efficiency. Radiopharmaceutical therapy (RPT) is an emerging approach that achieves precise radiation to diseased tissues via radionuclide delivery.
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