We investigated a possible synergistic effect of a macrolide and beta-lactams against Streptococcus pneumoniae strains with different resistance profiles. Checkerboard and time-kill assays of erythromycin combined with penicillin or cefotaxime essentially showed indifference, suggesting that these antibiotics in combinations in vitro act substantially as individuals in their activity against S. pneumoniae.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC149295 | PMC |
| http://dx.doi.org/10.1128/AAC.47.3.1151-1153.2003 | DOI Listing |
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