A study on organic nitrates, Part VI. Synthesis and pharmacological activity of 1-isopropylamino-3-(1-naphthyloxy)-2-propyl nitrate.

Basing on the studies on the relationship between the structure and activity, we have synthesized a nitrate analogue of propranolol as potential donor of nitric oxide. The obtained 1-isopropylamino-3-(1-naphthyloxy)-2-propyl nitrate decreases blood pressure more than propranolol and slows the heart rate less than propranolol. It also affects peripheral vascular resistance less than propranolol.