Background And Aims: To investigate the impact of obesity on joint pain, we examined the association of body mass index (BMI) with joint pain.
Methods: 351 community-dwelling Japanese women aged 40-85 years were asked about joint pain at specific joints, and height and weight were measured. Logistic regression analysis was used to evaluate BMI and other potential predictors of joint pain.
Results: BMI was positively associated with knee pain, but not with pain at other specific joints, after adjusting for age. The association of BMI with knee pain remained significant after adjustment for an additional covariate (physical activity). We also examined the associations of age, BMI, and regular physical activity with joint pain at any site, in the arm, in the leg, or in the back. Independently of age and regular physical activity, BMI was positively associated with joint pain in the leg, but not with pain at any site, in the arm or in the back. No significant association of physical activity with joint pain at any site, in the arm, in the leg or in the back was found.
Conclusions: Knee pain was associated with greater BMI. This finding supports previous longitudinal studies, suggesting that some knee pain could be prevented by avoidance of excess weight, if the association is causative. However, the association was not very strong; thus, it is likely that many cases of knee pain cannot be avoided by weight reduction only, and may require other interventions.
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http://dx.doi.org/10.1007/BF03324465 | DOI Listing |
Bioact Mater
April 2025
Research Center for Computer-aided Drug Discovery, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
The aberrant activation of the canonical Wnt/β-catenin signaling has been identified as a significant contributor to the pathogenesis of osteoarthritis (OA), exacerbating OA symptoms and driving OA progression. Despite its potential as a therapeutic target, clinical translation is impeded by the lack of a targeting delivery system and effective drug candidate that can modulate steady-state protein levels of β-catenin at post-translational level. Our study addresses these challenges by offering a new approach for OA treatment.
View Article and Find Full Text PDFCureus
December 2024
Orthopaedic Surgery, Singapore General Hospital, Singapore, SGP.
Background Multiple studies have shown that symptoms of knee osteoarthritis (OA) weakly correlate with the radiographic severity of the disease. Our objective was to determine possible correlations between the radiographic severity of knee OA and clinical manifestations such as disability, pain scores, and emotional health. Methods A retrospective review of registry data of 305 patients with knee OA was collected.
View Article and Find Full Text PDFCureus
December 2024
Clinical Research and Medical Writing, Meril Life Sciences Private Limited, Vapi, IND.
Aim The primary objective of the study was to evaluate the mid-term implant survivability, rate of revisions, and clinical and functional outcomes following patella resurfacing during total knee arthroplasty (TKA) utilizing posterior stabilized (PS) total knee system (TKS). Methods A prospective, single-arm, multi-center, post-marketing surveillance encompassed patients with end-stage primary knee osteoarthritis (OA) or inflammatory arthritis. The time points of the study included baseline, six weeks, six months, one year, and three years post-operatively.
View Article and Find Full Text PDFIowa Orthop J
January 2025
Department of Orthopedics and Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
Background: Hip dysplasia diagnosed after skeletal maturity is distinct from developmental dysplasia of the hip (DDH) in infants and young children. While the natural history of DDH in infants and young children is well-established, the association between hip dysplasia diagnosed after skeletal maturity and osteoarthritis is less clear. This narrative review summarizes existing literature assessing characteristics of hip dysplasia diagnosed after skeletal maturity associated with progression to osteoarthritis.
View Article and Find Full Text PDFIowa Orthop J
January 2025
University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
Background: Recognizing ACL injuries on the field and in the office can be very challenging in awake and apprehensive patients. Despite high specificity, many published "pivot-shift" techniques have limited acceptance mainly because of unsatisfactory sensitivity. We describe in detail, four specific modifications and provide a critical review of our clinical experiences to empower the new user's readiness to master a novel screening procedure for ACL disruption.
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