Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000068693 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Methylenetetrahydrofolate reductase () C677T and A1298C polymorphisms are associated with major depressive disorder in the Saudi patients attending Erada complex for mental health and Erada services - Jeddah, Saudi Arabia.
Pharmazie
December 2024
Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
: Major Depressive Disorder (MDD) is a prevalent and debilitating mental disorder that has been linked to hyperhomocysteinemia and folate deficiency. These conditions are influenced by the methylenetetrahydrofolate reductase () gene, which plays a crucial role in converting homocysteine to methionine and is essential for folate metabolism and neurotransmitter synthesis, including serotonin. : This study explored the association between and polymorphisms among Saudi MDD patients attending the Erada Complex for Mental Health and Erada Services outpatient clinic in Jeddah, Saudi Arabia.
View Article and Find Full Text PDFEffect of combination therapy of methylfolate with antidepressants in patients with depressive disorder.
BMC Pharmacol Toxicol
January 2025
Department of Community Medicine, Islamic International Medical College (IIMC), Riphah International University, Rawalpindi, Pakistan.
Objective: To determine the relative effectiveness of combination therapy of antidepressants with low-dose methylfolate versus antidepressant monotherapy in patients with depressive disorder.
Methods: In an open-label clinical trial, forty-four patients with depressive disorder (6A70, 6A71, and 6A72 according to ICD-11) received an evidence-based antidepressant therapy (either escitalopram 10-20 mg, sertraline 50-100 mg, fluoxetine 20-40 mg, duloxetine 30-60 mg, mirtazapine 15-30 mg, venlafaxine 75-150 mg, trazodone 50-100 mg, amitriptyline 25-75 mg, or clomipramine 25-75 mg orally daily for 4 weeks). The experimental group, Group B was additionally given a dose of methylfolate 800 µg daily for four weeks.
Urinary arsenic and depressive symptoms among adults: A moderated mediation analysis of folate and dietary inflammation index.
J Affect Disord
December 2024
Department of Breast Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China. Electronic address:
Background: Few studies have explored the effects of arsenic exposure on depressive symptoms and the underlying mechanisms of its influence on this relationship. This study aimed to assess the impact of urinary arsenic on depressive symptoms and the mediating and moderating roles of folate and dietary inflammation index (DII).
Methods: Cross-sectional data from 9775 participants (≥20 years) in the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2020 were used for analysis.
Association of Vitamin B12 and Polymorphism of with Early-Onset Post-Stroke Depression.
Neuropsychiatr Dis Treat
November 2024
Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410005, People's Republic of China.
Article Synopsis
- - The study investigates the connection between vitamin B12, folate, their transporter genes, and post-stroke depression (PSD) in 173 ischemic stroke patients, finding a significant link between low vitamin B12 levels and a high incidence of PSD (48.6%).
- - Results show that individuals with the GG genotype of the rs1801198 SNP have an increased risk of developing PSD, with odds ratios indicating a strong association after adjusting for other factors.
- - The findings suggest that vitamin B12 levels and the rs1801198 SNP may play a role in the onset of early PSD, offering new perspectives for potential treatments.
Associations between folate intake and knee pain, inflammation mediators and comorbid conditions in patients with symptomatic knee osteoarthritis.
BMC Musculoskelet Disord
November 2024
Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, Guangdong, China.
Background: To investigate the associations between folate intake and changes in knee pain, inflammation mediators and comorbid conditions over 2 years in patients with symptomatic knee osteoarthritis (OA).
Methods: A post-hoc analysis was performed based on data from the VIDEO study, a multicenter, randomized, double-blind, placebo-controlled clinical trial aimed at assessing the impact of vitamin D supplementation on patients with knee OA who were also vitamin D deficient. The original trial's design and inclusion and exclusion criteria were integrated into this subsequent post-hoc analysis.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!