AI Article Synopsis
- Chronic granulomatous disease (CGD) leads to frequent infections, primarily caused by specific bacteria and fungi.
- A study analyzed infection samples from CGD patients between 1992 and 2000, focusing on antibiotic resistance and strain differences of the pathogens involved in their recurrent infections.
- Findings revealed that most recurrent infections with specific bacteria like Burkholderia cepacia and S. aureus were due to new strains, suggesting that relapses often indicate new infections rather than the same one recurring.
Article Abstract
Chronic granulomatous disease (CGD) is characterized by severe recurrent infections with Staphylococcus aureus, certain gram-negative rods, Nocardia species, and fungi. When infections with the same species recur, they may represent relapses or new infections. We collected organisms from infections that occurred between 1992 and 2000 in patients with CGD and determined the biochemical phenotypes, in vitro antibiotic susceptibility patterns, and pulsed-field gel electrophoresis (PFGE) patterns of the organisms causing the initial and recurrent infections. Recurrence of infection with Burkholderia cepacia or Serratia marcescens was caused by a new strain in 9 of 10 cases (P=.001). Recurrent S. aureus infections were caused by new strains in 7 of 8 cases (P=.006). In patients with CGD, recurrence of infection with the same bacterial species after appropriate antibiotic therapy usually represents new infection.
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| http://dx.doi.org/10.1086/368388 | DOI Listing |
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