OBJECTIVE: To evaluate the free alpha subunit of human chorionic gonadotropin (FalphahCG) as a marker for pregnancy-induced hypertension (PIH). METHODS: The study group consisted of 74 pregnant women with hypertension. PIH admitted at 21-43 weeks of gestation. The control group was 37 non-PIH women. Serum FalphahCG was measured by radioimmunoassay with monoclonal technology. Using Youden's index of the receiver operator characteristic curve(ROC), a threshold value was determined. RESULTS: FalphahCG levels in PIH women were significantly higher than in the control group women [(556+/-428)IU/L compared with (232+/-131)IU/L,P<0.001].Using 260 IU/L of FalphahCG as the threshold value yields a sensitivity of 81.1% and specificity of 75.7% with a Youden's index of 0.57 for predicting PIH. CONCLUSION: Serum FalphahCG may serve as a useful marker to predict PIH.
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Article Synopsis
- Pregnancy-induced hypertension (PIH) is a serious condition that can lead to complications such as altered blood clotting and increased risks for both mothers and babies.
- A study comparing 110 pregnant women found that those with PIH had significantly lower platelet counts and abnormal coagulation markers, indicating higher risks for bleeding and clotting issues.
- The research highlights the importance of regularly monitoring blood clotting and blood cell levels in pregnant women with PIH to manage risks effectively and improve health outcomes.
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