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Assessing Bacteriological Profiles and Targeting Resistant Bacterial Superbugs to Develop an Antibiogram Aiding in Antibiotic Selection.
Cureus
December 2024
Department of Pharmacy Practice, Ratnam Institute of Pharmacy, Nellore, IND.
Introduction The success of surgical procedures is becoming more threatened by the advent of multi-drug resistant (MDR) bacterial strains, sometimes known as superbugs. These resistant microorganisms frequently cause post-surgical infections, which raise morbidity, death, and medical expenses. With an emphasis on resistant strains, this seeks to create an antibiogram and a thorough microbiological profile of surgical infections in order to help choose the most effective antimicrobial therapy.
View Article and Find Full Text PDFChronic Rhinosinusitis with Nasal Polyps and Biologics: A Call for Better Data Standardisation and Presentation in Clinical Studies.
Ther Clin Risk Manag
January 2025
Department of Otolaryngology Head & Neck Surgery, Monash Health, Melbourne, Australia.
Chronic rhinosinusitis with nasal polyps (CRSwNP) is often severe, debilitating and difficult to treat. Recent randomised control trials (RCTs) of biologics that target key inflammatory pathways have demonstrated clinical efficacy in treating CRSwNP. Such RCTs must facilitate meta-analysis.
View Article and Find Full Text PDFDevelopment and verification of prognostic nomogram for extraskeletal Ewing's sarcoma based on the SEER database.
Heliyon
January 2025
Hunan Cancer Hospital, Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410000, China.
Background: Extraskeletal Ewing's sarcoma (EES) is a rare tumor, and there is currently no predictive model for overall survival of EES patients. This study sought to use data from the Surveillance, Epidemiology, and End Results (SEER) database to develop a clinical predictive model that could be used to assess the prognosis of EES patients.
Methods: We selected and downloaded prognostic data on 356 patients diagnosed with extraskeletal Ewing's sarcoma based on screening criteria, These patients were distributed between 2004 and 2015.
Outcome of a Nail-plate Fixation Combination for a Distal Femur Fracture in a 99-year-old Patient.
J Orthop Case Rep
January 2025
Department of Orthopedic Surgery, NYU Langone Health, NYU Langone Orthopedic Hospital, New York, NY.
Introduction: This report describes the use of a combination of a retrograde femoral nail and distal femur locking plate for the treatment of an open intra-articular distal femur fracture in a 99-year-old female. The purpose of this report is to highlight that nail-plate fixation constructs can be performed percutaneously and expeditiously even in extremely old patients; therefore, patient age should not be a limiting factor in choosing this construct to allow for immediate weight-bearing.
Case Report: The patient was a 99-year-old female who presented to the emergency room after a fall.
Large language models (LLMs) represent a transformative class of AI tools capable of revolutionizing various aspects of healthcare by generating human-like responses across diverse contexts and adapting to novel tasks following human instructions. Their potential application spans a broad range of medical tasks, such as clinical documentation, matching patients to clinical trials, and answering medical questions. In this primer paper, we propose an actionable guideline to help healthcare professionals more efficiently utilize LLMs in their work, along with a set of best practices.
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