Background: We assessed the preventive effects of i.v. or i.p. lidocaine administration on increases in vascular resistance produced by carbon dioxide pneumoperitoneum and related this to vasopressin release.
Methods: Carbon dioxide pneumoperitoneum (14 mm Hg intra-abdominal pressure) was performed in 32 anaesthetized young pigs and monitored using a pulmonary artery catheter. Animals received lidocaine 0.5% (0.5 mg kg(-1)) i.v. (n=9) or 2 ml kg(-1) i.p. (n=9) or saline (n=5) 15 min before the pneumoperitoneum and were compared with a control group (n=9).
Results: I.V. and i.p. lidocaine inhibited increases in mean systemic vascular resistance induced by the pneumoperitoneum [2109 (SD 935) and 2282 (895), respectively, vs 3013 (1067) dyne s(-1) cm(-5) in the control group]. Cardiac output was increased. Plasma lidocaine concentrations were threefold higher after i.p. administration than after i.v. administration. After pneumoperitoneum insufflation, plasma lysine-vasopressin concentrations increased in all groups (control 74%, saline 65%, i.p. lidocaine 57%, i.v. lidocaine 74%).
Conclusions: I.V. and i.p. lidocaine blunted systemic vascular responses to carbon dioxide pneumoperitoneum in pigs, but without influencing vasopressin release.
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http://dx.doi.org/10.1093/bja/aeg080 | DOI Listing |
Nanotechnology
January 2025
Qingdao University, Ningxia Road 308, Qingdao, Shandong, 266071, CHINA.
Graphitic carbon nitride (g-C3N4) has gained significant attention as a promising nonmetallic semiconductor photocatalyst due to its photochemical stability, favorable electronic properties, and efficient light absorption. Nevertheless, its practical applications are hindered by limitations such as low specific surface area, rapid recombination of photogenerated charge carriers, poor electrical conductivity, and restricted photo-response ranges. This review explores recent advancements in the synthesis, modification and application of g-C3N4 and its nanocomposites with a focus on addressing these challenges.
View Article and Find Full Text PDFAnn Am Thorac Soc
January 2025
University of California San Francisco, Department of Epidemiology and Biostatistics, San Francisco, California, United States.
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January 2025
Division of Infectious Diseases, Department of Medicine II, Medical Centre and Faculty of Medicine, Albert-Ludwigs-University, Freiburg, Germany.
Background: Self-reported health problems following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are common and often include relatively non-specific complaints such as fatigue, exertional dyspnoea, concentration or memory disturbance and sleep problems. The long-term prognosis of such post-acute sequelae of COVID-19/post-COVID-19 syndrome (PCS) is unknown, and data finding and correlating organ dysfunction and pathology with self-reported symptoms in patients with non-recovery from PCS is scarce. We wanted to describe clinical characteristics and diagnostic findings among patients with PCS persisting for >1 year and assessed risk factors for PCS persistence versus improvement.
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January 2025
Plastic Surgery Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Hypertrophic scars (HTSs) are the result of an abnormal healing process resulting from burns and other severe traumas. The symptoms of that condition include skin irritation, discomfort, and itching. This study aimed to assess the efficacy of fractional carbon dioxide (CO) laser therapy alone or with triamcinolone or 5-fluorouracil (FU) in the treatment of early post-burn hypertrophic scars (HTSs) that develop during the first 6 months after the injury.
View Article and Find Full Text PDFNanomicro Lett
January 2025
Department of Chemical Engineering, Faculty of Science and Engineering, The University of Manchester, Manchester, M13 9PL, UK.
Polymers of intrinsic microporosity (PIMs) have received considerable attention for making high-performance membranes for carbon dioxide separation over the last two decades, owing to their highly permeable porous structures. However, challenges regarding its relatively low selectivity, physical aging, and plasticisation impede relevant industrial adoptions for gas separation. To address these issues, several strategies including chain modification, post-modification, blending with other polymers, and the addition of fillers, have been developed and explored.
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