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Discovery of antimicrobial activity in chemical extracts derived from unexplored algal-bacterial culture systems and isolates.
Sci Rep
December 2024
Bioresource and Environmental Security, Sandia National Laboratories, P. O. Box 969, Livermore, CA, 94551-0969, USA.
Global health is affected by viral, bacterial, and fungal infections that cause chronic and often fatal diseases. Identifying novel antimicrobials through innovative methods that are active against human pathogens will create a new, necessary pipeline for chemical discovery and therapeutic development. Our goal was to determine whether algal production systems represent fertile ground for discovery of antibiotics and antifungals.
View Article and Find Full Text PDFThrow out an oligopeptide to catch a protein: Deep learning and natural language processing-screened tripeptide PSP promotes Osteolectin-mediated vascularized bone regeneration.
Bioact Mater
April 2025
Department of Oral and Cranio-maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Shanghai Research Institute of Stom, Shanghai, 200011, China.
Article Synopsis
- Angiogenesis is crucial for bone regeneration, but traditional cytokine therapies face challenges like high costs and safety concerns.
- Using Deep Learning and Natural Language Processing, researchers developed a new algorithm to identify promising pro-angiogenic peptides from disordered regions of proteins, highlighting the potential for safer bioactive peptides.
- One notable tripeptide, PSP, significantly promotes vascularization and osteogenic differentiation in stem cells, showcasing its role as a 'priming' agent that enhances the body's natural bone formation processes.
Generalized pustular psoriasis: immunological mechanisms, genetics, and emerging therapeutics.
Trends Immunol
January 2025
College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Dermatology, Chang Gung Memorial Hospital, Keelung, Taiwan; Department of Dermatology, Chang Gung Memorial Hospital, Linkou, Taiwan; Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan; Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou, Taiwan; Cancer Vaccine and Immune Cell Therapy Core Laboratory, Department of Medical Research, Chang Gung Memorial Hospital, Linkou, Taiwan; Chang Gung Immunology Consortium, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan; Department of Dermatology, Xiamen Chang Gung Hospital, Xiamen, China; Xiamen Chang Gung Allergology Consortium, Xiamen Chang Gung Hospital, Xiamen, China; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Immune-Oncology Center of Excellence, Chang Gung Memorial Hospital, Linkou, Taiwan; Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan; Genomic Medicine Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taiwan; School of Medicine, National Tsing Hua University, Hsinchu, Taiwan. Electronic address:
Generalized pustular psoriasis (GPP) is a rare human autoinflammatory disorder with life-threatening systemic effects. Keratinocyte-derived interleukin (IL)-36 signaling has been identified as a key mediator of immune response in the skin of affected individuals. Recognition of various mutations along the IL-36 axis and the downstream nuclear transcription factor κB (NF-κB) signaling have established GPP as genetically, immunologically, and histopathologically distinct and amenable to immunomodulation, which is epitomized by the recent success of IL-36 antagonism.
View Article and Find Full Text PDFFaced with the increasingly serious problem of water scarcity, developing precise irrigation strategies for crops in saline alkali land can effectively reduce the negative effects of low water resource utilization. Using a model to simulate the dynamic changes in soil water and salt environment in the root zone of fragrant pear trees in saline alkali land, and verifying them from a production practice perspective with comprehensive benefits as the goal, can optimize the irrigation amount and irrigation technology elements of saline alkali fruit trees, broaden the comprehensive evaluation perspective of decision-makers, and have important significance for improving the yield and production efficiency of forestry and fruit industry in arid and semi-arid areas worldwide. In this study, a two-year field experiment based on three irrigation levels (3000, 3750, and 4500 m·ha) and four emitter discharge rates (1, 2, 3, and 4 L·h) was conducted in Xinjiang, China.
View Article and Find Full Text PDFEmergence of Exotic Spin Texture in Supramolecular Metal Complexes on a 2D Superconductor.
Phys Rev Lett
December 2024
Department of Applied Physics, Aalto University, FI-00076 Aalto, Finland.
Article Synopsis
- Designer heterostructures combining supramolecular metal complexes (SMCs) and the quasi-2D superconductor NbSe₂ were developed to create unique superconducting states through the interplay of magnetism and superconductivity.
- Scanning tunneling microscopy revealed the formation of Yu-Shiba-Rusinov bands due to interactions between SMC magnetism and NbSe₂ superconductivity, while additional measurements indicated antiferromagnetic coupling among SMC units.
- The resulting unconventional 3×3 magnetic reconstruction could lead to innovative quantum materials, advancing the research of unconventional superconductors and quantum spin liquids.
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