The aim of this study was to investigate the relationship between plasma ET-1 levels and T helper-1 (Th1):Th2 immunity in women with twin pregnancies. The percentage of Th1 and Th2 cells and the Th1:Th2 cell ratios in peripheral blood from 13 normal singleton pregnant women and 13 patients with twin pregnancies at 29-34 weeks' gestation were calculated using flow cytometry. The plasma ET-1 was also determined using a modified radioimmunoassay. The plasma ET-1 concentrations and the cell ratios of Th1:Th2 in twin pregnancies were significantly lower than those in singleton pregnancies. A positive correlation was found between plasma ET-1 levels and the ratios of Th1:Th2 cells in the whole subjects. Our results indicate that decreased ET-1 levels are associated with Th1:Th2 immunity in twin pregnancies.
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