Nonhealing wounds in cats are a source of frustration for veterinarians and pet owners alike. These wounds are known for their insidious onset and tendency to recur after standard surgical closure. The presence of a feline wound that fails to heal in the face of appropriate therapy should initiate an extensive diagnostic evaluation for an etiologic agent. Initially animals should be screened for causes of immunosuppression or systemic disease. The local wound environment should then be evaluated through a combination of wound exploration, cytology, histopathology and tissue culture for evidence of a foreign body, neoplasia, or other less common etiologies of these wounds. Many of the less common etiologic agents require specific tissue handling for successful microscopic identification and culture. It is therefore essential for veterinarians to be familiar with the various causes of nonhealing wounds in cats so that laboratories can be alerted of the need for specific diagnostic techniques. Recent surgical and medical advances have the potential to facilitate the successful treatment of these wounds. With improved veterinary awareness of the potential etiologies of nonhealing wounds in cats and improved medical and surgical management techniques many wounds can now successfully be treated.
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http://dx.doi.org/10.1053/svms.2002.36603 | DOI Listing |
Int J Biol Macromol
January 2025
Department of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR China; Department of Emergency, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR China. Electronic address:
Diabetic wounds often exhibit a chronic non-healing state due to the combined effects of multiple factors, including hyperglycemia, impaired angiogenesis, immune dysfunction, bacterial infection, and excessive oxidative stress. Despite the availability of various therapeutic strategies, effectively managing the complex and prolonged healing process of diabetic infected wounds remains challenging. In this study, we combined the natural antidiabetic drug lipoic acid (LA) with the RADA16-YIGSR (RY) peptide obtained through solid-phase synthesis, utilizing reversible hydrogen bonds and coordination bonds for binding.
View Article and Find Full Text PDFJ Clin Med
December 2024
Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University of Graz, 8036 Graz, Austria.
Non-healing soft tissue defects pose challenges to treating physicians. Microsurgical reconstruction is a treatment option for achieving wound closure and limb salvage. These free tissue transfers are often challenging due to associated risk factors.
View Article and Find Full Text PDFAdv Skin Wound Care
January 2025
At Mayo Clinic, Rochester, Minnesota, United States, Paul T. Gomez, BS, is Summer Research Fellow, Regenerative Sciences Track, Mayo Clinic Graduate School of Biomedical Sciences; Saranya P. Wyles, MD, PhD, is Consultant, Department of Dermatology; and Karen L. Andrews, MD, is Director, Vascular Ulcer and Wound Healing Clinic/Gonda Vascular Center, and Consultant, Department of Physical Medicine and Rehabilitation. At Mayo Clinic, Jacksonville, Florida, Jennifer R. Arthurs is APRN, Center for Regenerative Medicine; and Alison J. Bruce, MB, ChB, is Consultant, Department of Dermatology.
Background: Chronic nonhealing neuropathic foot ulcers affect approximately 15% to 30% of patients with diabetes mellitus and are associated with significant morbidity and mortality. Although current strategies to address these chronic wounds include a multifactorial approach, clinical outcomes remain poor and warrant improvement. Platelet-rich plasma (PRP), derived from autologous or allogeneic blood, is an emerging regenerative product that aims to serve as an adjuvant to standard diabetic foot ulcer (DFU) treatment.
View Article and Find Full Text PDFExpert Opin Drug Deliv
January 2025
Smart Materials, Istituto Italiano di Tecnologia, Genova, Italy.
Introduction: Chronic non-healing wounds have emerged as a significant global healthcare challenge. Biofilm induced wound infections has been widely acknowledged. Despite the advanced understanding of biofilm formation, the existing approaches for diagnosing biofilms in wounds remain considerably suboptimal.
View Article and Find Full Text PDFCureus
December 2024
Internal Medicine, AdventHealth Orlando, Orlando, USA.
spp. rarely cause infection in humans and are most common in the immunocompromised population. Pulmonary nocardiosis is the most common presentation.
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