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BPDCN: state of the art.
Hematology Am Soc Hematol Educ Program
December 2024
Department of Leukemia, University of Texas, MD Anderson Cancer Center, Houston, TX.
Article Synopsis
Navigating diagnostic dilemmas: a rare presentation of extramedullary T-lymphoblastic leukemia/lymphoma with chronic myeloid leukemia.
J Hematop
December 2024
Department of Pathology, Microbiology, and Immunology University of Nebraska Medical Center, Omaha, NE, USA.
Chronic myeloid leukemia (CML) typically presents in the chronic phase. The blast crisis phase in CML predominantly comprises the myeloid phenotype, while B-cell lymphoblastic crisis is common among the lymphoid lineages. Presentation as a T-lymphoblastic crisis is exceptionally rare.
View Article and Find Full Text PDFSite-discordant expression of myeloid cell nuclear differentiation antigen in blastic plasmacytoid dendritic cell neoplasm.
Am J Clin Pathol
September 2024
Department of Pathology, Stanford University School of Medicine, Stanford, CA, US.
Article Synopsis
- Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, aggressive blood cancer that shares similarities with acute myeloid leukemia, making it challenging to diagnose.
- A study re-evaluating the expression of myeloid cell nuclear differentiation antigen (MNDA) in BPDCN found considerable variability in MNDA expression across different tissue samples.
- The results indicate that MNDA expression is influenced by the anatomical site and may be transient, suggesting that it shouldn't be solely relied upon to differentiate BPDCN from other conditions in tests.
Immunohistochemical differentiation of extramedullary acute myeloid leukemia from blastic plasmacytoid dendritic cell neoplasm.
Int J Hematol
October 2024
Department of Hematology, Yokohama Municipal Citizen's Hospital, 1-1 Mitsuzawa Nishimachi, Kanagawa-Ku, Yokohama, Kanagawa, 221-0855, Japan.
A rare case of Blastic plasmacytoid dendritic cell neoplasm with gynecologic presentation.
Leuk Res Rep
May 2024
Department of obstetrics and gynecology, Tahar Sfar university hospital 5111 Mahdia, Tunisia.
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematological malignancy characterized by the proliferation of plasmacytoid dendritic cells with a blast-like appearance. It usually presents in elderly people, and clinical manifestations include nodular blue-violet skin lesions, bone marrow infiltration and, less frequently, extramedullary involvement. Gynecological manifestation (breast mass and exocervical lesion) is an unusual and rare presentation.
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