Purpose Of Review: Immediate allergic reactions to natural rubber latex continue to be an important medical and occupational health problem. In this review we focus on progress made in understanding the significance of occupational exposure and epidemiology, risk groups, diagnosis and prevention of natural rubber latex allergy. We also discuss methods aimed at quantification of clinically relevant natural rubber latex allergens and studies on B-cell epitopes of major natural rubber latex allergens.
Recent Findings: Prospective studies have been published focusing on the prevention of natural rubber latex allergy. Efforts to identify and characterize new natural rubber latex allergens were continued in several research groups. The use of purified allergens or proteins produced by recombinant DNA technology was assessed in studies aimed at improving the diagnosis of natural rubber latex allergy as well as in developing quantitative methods for the measurement of specific natural rubber latex allergens. For the first time, conformational immunoglobulin E epitopes were identified in a major natural rubber latex allergen, hevein, using a novel chimera-based allergen epitope mapping strategy.
Summary: Measures taken in health care to reduce exposure to natural rubber latex products seem to be effective in reducing the number of new sensitizations. A few new minor natural rubber latex allergens, probably important in allergen cross reactions, were identified, and some nonmedical natural rubber latex products were found to be potentially dangerous to natural rubber latex-allergic patients. Sensitive and specific immunoassays for quantification of clinically relevant natural rubber latex allergens in manufactured products were developed in some laboratories. These assays may eventually replace the nonspecific total protein measurement, currently advocated by health authorities in the indirect estimation of allergen amounts in natural rubber latex products. Knowledge about conformational immunoglobulin-binding B-cell epitopes of major allergens is expected to be helpful in designing optimal reagents to specific immunotherapy.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1097/00130832-200210000-00007 | DOI Listing |
RSC Adv
January 2025
Regenerative Medicine and Tissue Repair Material Research Center, HuangpuInstitute of Materials 88 Yonglong Avenue of Xinlong Town Guangzhou 511363 P. R. China.
As a well-known aromatic herb rich in various bioactive molecules, the extract of is widely used in cosmetics. However, the extraction process for is far from perfect. Moreover, the water- and oil-soluble components are too complex to be compatible with each other.
View Article and Find Full Text PDFFront Chem
January 2025
Key laboratory of Rubber-Plastic of Ministry of Education /Shandong Province (QUST), School of Polymer Science and Engineering, Qingdao University of Science and Technology, Qingdao, China.
Perovskite solar cells (PVSCs) show remarkable potential due to their high-power conversion efficiencies and scalability. However, challenges related to stability and long-term performance remain significant. Self-assembled monolayers (SAMs) have emerged as a crucial solution, enhancing interfacial properties, facilitating hole extraction, and minimizing non-radiative recombination.
View Article and Find Full Text PDFClin Neurophysiol Pract
December 2024
Department of Rehabilitation Medicine, Shanghai Jing'an District Central Hospital, Shanghai, China.
Objective: To elucidate the immediate electrophysiological effects of mirror visual feedback (MVF) combined with or without touch task in subacute stroke.
Methods: Subacute stroke patients and healthy controls were recruited to participate in four grasping tasks (MVF or no MVF, combined with rubber ball or no ball) under electroencephalogram (EEG) monitoring. Event-related desynchronization (ERD) /event-related synchronization (ERS) and the lateralization index (LI) were utilized to observe the electrophysiological effects.
J Mol Model
January 2025
Department of Astronautic Science and Mechanics, Harbin Institute of Technology, Harbin, 150006, People's Republic of China.
Context: The influence of fullerene C60 on the mechanical and thermal properties of natural rubber was systematically investigated using coarse-grained molecular dynamics simulations. The tensile results demonstrate that systems with longer NR chains exhibit reduced tensile strength. Moreover, the addition of C60 nanoparticles significantly enhanced the mechanical properties, with Young's modulus, yield strength, and tensile strength increasing by approximately 24.
View Article and Find Full Text PDFEnviron Sci Technol Lett
January 2025
EaStCHEM School of Chemistry, University of Edinburgh, Joseph Black Building, David Brewster Rd, Edinburgh, EH9 3FJ, United Kingdom.
Detecting and quantifying tire wear particles (TWPs) in the environment pose a unique environmental challenge due to their chemical complexity. There are emerging concerns around TWPs due to their potential high numbers of particles released, outnumbering microplastics, as well as the leaching of toxic additives such as 6-PPD which has been linked to the death of salmon even when present at very low levels (<0.1 μg/L).
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!