Background: A validated measure to assess sicca-related symptoms in patients with primary Sjögren's syndrome (1 degrees SS) is required for clinical studies.
Methods: A self-administered questionnaire was developed to assess sicca-related symptoms and dysfunction in 1 degrees SS. This was administered to three groups of 40 respondents to measure construct validity: 1 degrees SS patients, non-SS patients reporting xerostomia and a non-patient group. The frequency of scores and the mean score for each question were calculated for each group. Reliability was assessed by test/retest.
Results: The measure consisted of 28 items divided into five domains. Scores for questions in domains were generally worse (higher) for 1 degrees SS patients than for patients with xerostomia. The non-patient group reported the best (lowest) scores for all questions. The Kappa statistic for all but four questions was greater than 0.6, suggesting good reliability.
Conclusion: Questionnaire showed good construct validity and reliability. The Liverpool sicca index needs to be further validated in larger, multicentre studies.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1034/j.1600-0714.2003.t01-1-00109.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Severe treatment-refractory antibody positive autoimmune autonomic ganglionopathy after mRNA COVID19 vaccination.
Autoimmun Rev
December 2022
Department of Clinical Immunology and Allergy, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
Background: COVID-19 vaccine-associated peripheral and central neuroimmunological disorders have been well described. We present the case of a 56 year old male who developed α3-ganglionic AChR antibody positive Autoimmune Autonomic Ganglionopathy (AAG) after completion of a two-dose course of mRNA (Comirnaty) vaccination for COVID19.
Results: A previously hypertensive 56 year old male presented with the subacute onset of severe constipation, urinary retention, erectile dysfunction, sudomotor failure, sicca symptoms, non-reactive pupils and severe orthostatic hypotension shortly after receiving the second dose of an mRNA vaccine against COVID19.
Episcleral cyclosporine A implants for the management of unilateral keratoconjunctivitis sicca in an 8-year-old mare.
Vet Ophthalmol
January 2017
Philip Leverhulme Equine Hospital, School of Veterinary Science, University of Liverpool, Leahurst Campus, Neston, Wirral, CH64 7TE, UK.
An 8-year-old mare was presented for investigation of a 1-month history of blepharospasm, eyelid swelling, corneal edema, and ocular discharge of the right eye (OD). Ophthalmic examination confirmed mucopurulent ocular discharge, conjunctival hyperemia, and a dry, dull appearance to the cornea OD. Schirmer tear test results confirmed an absence of tear production OD (0 mm/min) consistent with keratoconjunctivitis sicca.
View Article and Find Full Text PDFDo the EULAR Sjögren's syndrome outcome measures correlate with health status in primary Sjögren's syndrome?
Rheumatology (Oxford)
April 2015
Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the London NHS Trust & Barts and the London School of Medicine and Dentistry, NHS Fife, Whyteman's Brae Hospital, Kirkcaldy, Royal Hampshire County Hospital, Winchester, Royal Derby Hospital, Derby, University College London Hospitals NHS Foundation Trust, London, Queen Elizabeth Hospital, Gateshead, Sunderland Royal Hospital, Sunderland, Southend University Hospital, Royal National Hospital for Rheumatic Diseases, Bath, Portsmouth Hospitals NHS Trust, Aintree University Hospitals, Liverpool, Basildon Hospital, Basildon, Royal Hallamshire Hospital, Sheffield, UK. Newcastle upon Tyne Hospitals NHS Foundation Trust, Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases, Institute of Health and Society, Newcastle University, Newcastle upon Tyne, Musgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, University Hospital Birmingham, Birmingham, Great Western Hospitals NHS Foundation Trust, Swindon, Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, Nottingham University Hospital, Nottingham, Gartnavel General Hospital, Glasgow, Barts and the
Objective: This study sets out to investigate the relationship between health status [EuroQol five-dimensions questionnaire (EQ-5D)] in primary SS and three of the European League Against Rheumatism (EULAR) SS outcome measures-the disease activity index (ESSDAI), the patient reported index (ESSPRI) and the sicca score. In particular, the goal was to establish whether there is a relationship between the EULAR outcome measures and quality of life.
Methods: Health status was evaluated using a standardized measure developed by the EuroQol Group-the EQ5D.
The development and initial validation of the Liverpool sicca index to assess symptoms and dysfunction in patients with primary Sjögren's syndrome.
J Oral Pathol Med
March 2003
Sjögren's Syndrome Research Group, Department of Clinical Dental Sciences, University of Liverpool, UK.
Background: A validated measure to assess sicca-related symptoms in patients with primary Sjögren's syndrome (1 degrees SS) is required for clinical studies.
Methods: A self-administered questionnaire was developed to assess sicca-related symptoms and dysfunction in 1 degrees SS. This was administered to three groups of 40 respondents to measure construct validity: 1 degrees SS patients, non-SS patients reporting xerostomia and a non-patient group.
Epstein-Barr virus (types 1 and 2) in the tear film in Sjogren's syndrome and HIV infection.
J Med Virol
November 2002
St. Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, United Kingdom.
Evidence of Epstein-Barr virus (EBV) shedding in the saliva and tear film has been sought to explain the pathogenesis of the oral and ocular features of Sjogren's syndrome. Patients with human immunodeficiency virus (HIV) infection are purported to have a higher incidence of keratoconjunctivitis sicca. Twenty patients with definite Sjogren's syndrome (primary and secondary), 19 with HIV infection, and 15 normal controls were recruited and studied.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!