Initial agonist treatment of Parkinson disease: a critique. | LitMetric

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Initial agonist treatment of Parkinson disease: a critique. | LitMetric

Initial agonist treatment of Parkinson disease: a critique.

Roger L Albin Kirk A Frey

Neurology

Department of Neurology, Geriatric Research, Education, and Clinical Center, Ann Arbor VAMC, University of Michigan, Ann Arbor, USA.

Published: February 2003

The evidence supporting initial dopamine agonist treatment of PD is reviewed. The two rationales for initial agonist treatment are reduced frequency of motor complications and possible relative neuroprotection by dopamine agonists. The basic science supporting these rationales is equivocal. The clinical evidence for advantages of initial agonist treatment is incomplete. More data are required to determine the optimal initial treatment for PD.

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http://dx.doi.org/10.1212/01.wnl.0000052681.28286.52	DOI Listing

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