Aim: To investigate whether tazobctam has crystallization water.
Methods: In order to establish a method for water content determination in tazobctam, many methods including Karl Fischer titration, weight loss on drying, TGA, DSC and X-ray diffraction experiment of an orthorhombic form were studied.
Results: The water content of the same batch tazobactam determined by different mthods was different.
Conclusion: The results showed that one mole tazobatam contains half mole water of crystallization and the strength of attraction between tazobatam molecule and water molecule is rather strong.
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