The optimal imaging conditions for 3D brain surface imaging by magnetic resonance imaging (MRI) and multi-slice CT were investigated. Visualization of the sulci, gyri, and veins on the brain's surface was also compared between 3D surface images acquired using multi-slice CT and conventional single-slice CT and MRI. Various imaging parameters, including slice thickness, dose, and matrix size, were evaluated using our original brain surface phantom and longitudinal direction evaluation phantom as well as images obtained from healthy volunteers. Subjects of the clinical study were patients with arteriovenous malformations and brain tumors who underwent CT-angiography at the same time as MR-angiography. The quality of 3D images of the brain surface is most strongly influenced by partial volume effects related to slice thickness. In multi-slice CT, a slice thickness of 0.5 mm can be employed to minimize the partial volume effect, providing results that are far superior to those that can be achieved by conventional single-slice 3D-CT. In addition, the excellent S/N of multi-slice CT permits the veins on the brain's surface to be clearly visualized without the use of contrast medium. With regard to visualization of the sulci and gyri, although some problems remain to be overcome, multi-slice CT was found to be equivalent to 3D surface imaging using MRI.
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Nanotechnology
January 2025
Xi'an Jiaotong University, xian ning west road 28#, xi'an, Xi'an, None Selected, 710049, CHINA.
Accurate and rapid diagnosis of traumatic brain injury (TBI) is essential for high-quality medical services. Nonetheless, the current diagnostic platform still has challenges in rapidly and accurately analysing clinical samples. Here, we prepared a highly stable, repeatable and sensitive gold-plated silver core-shell nanowire (Ag@AuNWs) for surface-enhanced Raman spectroscopy (SERS) metabolic fingerprint diagnosis of TBI.
View Article and Find Full Text PDFCell Rep
January 2025
Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, South Korea; Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul 03080, South Korea; Transplantation Research Institute, Medical Research Center, Seoul National University, Seoul 03080, South Korea. Electronic address:
Cd99 molecule-like 2 (Cd99l2) is a type I transmembrane protein that plays a role in the transmigration of leukocytes across vascular endothelial cells. Despite its high expression in the brain, the role of Cd99l2 remains elusive. We find that Cd99l2 is expressed primarily in neurons and positively regulates neurite outgrowth and the development of excitatory synapses.
View Article and Find Full Text PDFAnalyst
January 2025
Department of Engineering and Architecture, University of Trieste, via A. Valerio 6, 34127 Trieste, Italy.
Ergothioneine (ERG) is a natural sulfur-containing amino acid found in many organisms, including humans. It accumulates at high concentrations in red blood cells and is distributed to various organs, including the brain. ERG has numerous health benefits and antioxidant capabilities, and it has been linked to various human physiological processes, such as anti-inflammatory, neuroprotective, and anti-aging effects.
View Article and Find Full Text PDFBMJ Open
December 2024
British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
Introduction: Ischaemic heart disease (IHD) and cerebrovascular disease are leading causes of morbidity and mortality worldwide. Cerebral small vessel disease (CSVD) is a leading cause of dementia and stroke. While coronary small vessel disease (coronary microvascular dysfunction) causes microvascular angina and is associated with increased morbidity and mortality.
View Article and Find Full Text PDFMol Neurobiol
January 2025
Department of Neurology, Huai'an First People's Hospital, The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University, No.1 Huanghe West Road, Huai'an, 223300, Jiangsu, China.
A comprehensive genome-wide association study (GWAS) has validated the identification of the Plexin-A 4 (PLXNA4) gene as a novel susceptibility factor for Alzheimer's disease (AD). Nonetheless, the precise role of PLXNA4 gene polymorphisms in the pathophysiology of AD remains to be established. Consequently, this study is aimed at exploring the relationship between PLXNA4 gene polymorphisms and neuroimaging phenotypes intimately linked to AD.
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