AI Article Synopsis
- Paeonia radix, the root of Paeonia japonica, was studied for its effects on treadmill exercise performance and the synthesis of 5-hydroxytryptamine (5-HT) in the brain.
- The results showed that Paeonia radix treatment increased the time to exhaustion during exercise but suppressed the exercise-induced increases in 5-HT synthesis and tryptophan hydroxylase (TPH) expression.
- Overall, this suggests that Paeonia radix may help reduce fatigue by inhibiting 5-HT synthesis and TPH expression, impacting both exercise and resting states.
Article Abstract
Paeonia radix is the root of Paeonia japonica MIYABE, a perennial plant classified in the family Paeoniaceae. In the present study, the effects of Paeonia radix on performance in treadmill exercise, and 5-hydroxytryptamine (5-HT) synthesis and tryptophan hydroxylase (TPH) expression in the dorsal raphe were investigated. Time to exhaustion in treadmill exercise was increased and exercise-induced increases in 5-HT synthesis and TPH expression in the dorsal raphe were shown to be suppressed by Paeonia radix treatment; 5-HT synthesis and TPH expression were inhibited by Paeonia radix treatment under resting conditions as well. In sum, treatment with Paeonia radix, inhibiting 5-HT synthesis and TPH expression, may bring about reduced fatigue, both during exercise and the resting state.
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| http://dx.doi.org/10.1248/bpb.26.166 | DOI Listing |
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