Stress proteins are highly conserved proteins that are essential for cell survival. In this study, the induction of general and specific stress proteins in Actinobacillus actinomycetemcomitans cells subjected to different stress conditions was evaluated by two-dimensional SDS-PAGE analysis. Twenty-eight (up- or down)regulated proteins, including DnaK and GroEL proteins, were identified as general stress proteins. In addition, eighteen regulated proteins were classified as pH stress-specific proteins, ten as acid stress-specific proteins, five as alkaline stress-specific proteins, three as heat stress-specific proteins, and ten as acid/heat stress-specific proteins. Further proteomic studies are required to determine the exact nature of the proteins regulated during the stress response of A. actinomycetemcomitans.
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http://dx.doi.org/10.1016/s0923-2508(02)00002-5 | DOI Listing |
Introduction: Acute kidney injury is characterized by high morbidity and mortality, with renal ischemia/reperfusion (I/R) injury as a critical inducer. Shikonin is the major bioactive compound extracted from the roots of Lithospermum erythrorhizon and possesses diverse pharmacological properties. This study was designed to investigate the biological functions of shikonin in renal I/R injury.
View Article and Find Full Text PDFAntioxidants (Basel)
October 2024
Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Normotensive and hypertensive organisms respond differently to stress factors; however, the features of the central molecular genetic mechanisms underlying the reaction of the hypertensive organism to stress have not been fully established. In this study, we examined the transcriptome profiles of the hypothalamus of hypertensive ISIAH rats, modeling a stress-sensitive form of arterial hypertension, and normotensive WAG rats at rest and after exposure to a single short-term restraint stress. It was shown that oxidative phosphorylation is the most significantly enriched process among metabolic changes in the hypothalamus of rats of both strains when exposed to a single short-term restraint stress.
View Article and Find Full Text PDFMethods Mol Biol
November 2024
Molecular and Cellular Biology, University of Arizona, Tucson, AZ, USA.
FOXO transcription factors respond to a number of different stresses by shuttling from the cytoplasm to the nucleus where they upregulate hundreds of target genes with diverse cellular functions. The cellular consequences of FOXO activation are both stress and cell-type specific. Recent evidence suggests that one way in which FOXO dictates stress-specific outcomes is through distinct nuclear/cytoplasmic shuttling dynamics.
View Article and Find Full Text PDFSci Rep
November 2024
Institute for Cellular and Molecular Botany, University of Bonn, Kirschallee 1, 53115, Bonn, Germany.
Secondary messengers, such as calcium ions (Ca), are integral parts of a system that transduces environmental stimuli into appropriate cellular responses. Different abiotic and biotic stresses as well as developmental processes trigger temporal increases in cytosolic free Ca levels by an influx from external and internal stores. Stimulus-specificity is obtained by a certain amplitude, duration, oscillation and localisation of the response.
View Article and Find Full Text PDFFront Plant Sci
October 2024
College of Agriculture, Institute of Molecular Agriculture and Bioenergy, Shanxi Agricultural University, Jinzhong, Shanxi, China.
Calcium-dependent protein kinases (CDPKs) serve as calcium ion sensors and play crucial roles in all aspects of plant life cycle. While gene family has been extensively studied in various plants, there is limited information available for members in oat, an important cereal crop worldwide. Totally, 60 genes were identified in oat genome and were classified into four subfamilies based on their phylogenetic relationship.
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