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First-in-Human: Simultaneous Hyperpolarized 1- 13 C-Pyruvate Magnetic Resonance Spectroscopy and 18 F-FDG PET (hyperPET) Imaging of a Patient With Lymphoma.
Clin Nucl Med
February 2025
Department of Health Technology, Technical University of Denmark, Lyngby, Denmark.
Hyperpolarized 1- 13 C-pyruvate magnetic resonance spectroscopy (MRS) and MRS imaging (MRSI) offer noninvasive and real-time direct assessment of the altered metabolism of cancer cells known as the Warburg effect-a key hallmark of cancer. When combined with simultaneously acquired 18 F-FDG PET in a PET/MR scanner, coined hyperPET by us, this dual-modality may unveil cancer-type specific glucose metabolic phenotypes with potential implications for patient prognostication, treatment-response assessment, and prediction. We here present the first human data of simultaneously acquired hyperpolarized MRS/MRSI and PET performed in a PET/MR scanner-and the first human hyperpolarized MRS/MRSI data from a patient with lymphoma.
View Article and Find Full Text PDFDevelopment of [F]DASA-10 for enhanced imaging of pyruvate kinase M2.
Nucl Med Biol
November 2023
Department of Radiology, Molecular Imaging Program at Stanford, Stanford University, Stanford, CA 943065, USA. Electronic address:
Purpose: The aim of this study was to develop a positron emission tomography (PET) radiotracer for measuring pyruvate kinase M2 (PKM2) with improved physicochemical and pharmacokinetic properties compared to [F]DASA-23.
Experimental Design: First, we synthesized [F]DASA-10 and tested its uptake and retention compared to [F]DASA-23 in human and mouse glioma cell lines. We then confirmed the specificity of [F]DASA-10 by transiently modulating the expression of PKM2 in DU145 and HeLa cells.
Inhibition of pyruvate carboxylase reverses metformin resistance by activating AMPK in pancreatic cancer.
Life Sci
August 2023
Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:
Aims: Pyruvate carboxylase (PC) plays a key role in cancer cell metabolic reprogramming. Whether metabolic reprogramming and PC are related in PDAC is unclear. Here, the effect of PC expression on PDAC tumorigenesis and metabolic reprogramming were evaluated.
View Article and Find Full Text PDFThe role of (F)-fluoro-D-glucose positron emission tomography/computed tomography in the surveillance of abnormal myocardial energy metabolism and cardiac dysfunction in a rat model of cardiopulmonary resuscitation.
Diagn Interv Radiol
May 2023
Department of Emergency, the Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, China.
Purpose: To investigate the feasibility and usefulness of 2-deoxy-2-(F)-fluoro-D-glucose positron emission tomography/computed tomography [(F)-FDG PET/CT] as a novel examination in the surveillance of abnormal myocardial energy metabolism and cardiac dysfunction after cardiopulmonary resuscitation (CPR).
Methods: Thirteen male Sprague-Dawley rats were randomly divided into a sham group (n = 4), CPR group (n = 4), and trimetazidine (TMZ) + CPR group (n = 5). The expression levels of the myocardial injury marker cardiac troponin I (CTNI) in serum were tested at 6 hours after CPR or TMZ + CPR.
Interplay of Metabolome and Gut Microbiome in Individuals With Major Depressive Disorder vs Control Individuals.
JAMA Psychiatry
June 2023
Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
Importance: Metabolomics reflect the net effect of genetic and environmental influences and thus provide a comprehensive approach to evaluating the pathogenesis of complex diseases, such as depression.
Objective: To identify the metabolic signatures of major depressive disorder (MDD), elucidate the direction of associations using mendelian randomization, and evaluate the interplay of the human gut microbiome and metabolome in the development of MDD.
Design, Setting And Participants: This cohort study used data from participants in the UK Biobank cohort (n = 500 000; aged 37 to 73 years; recruited from 2006 to 2010) whose blood was profiled for metabolomics.
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