[Simultaneous determination of four components in the compound child phenobarbital tablet using ultraviolet spectrophotometry].

Hunan Yi Ke Da Xue Xue Bao

Department of Chemistry, Xiangya School of Medicine, Central South University, Changsha 410078, China.

Published: February 2002

Objective: To establish a method to determine four components in the child phenobarbital tablet.

Methods: Ultraviolet spectrophotometry was used to determine four components without separation.

Results: The contents of aspirin, phenacetin, caffeine and phenobarbital could be measured simultaneously. The average recoveries of four components in simulated samples and the compound child phenobarbital tablet samples were 99.0%, 98.9%, 99.8%, and 101%, respectively, and relative standard deviations of those were 2.0%, 2.0%, 2.9%, and 2.2%, respectively.

Conclusion: The method is simple, fast, reliable, and can be used to monitor the quality of compound drugs.

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