Objectives: Two steps in stapedotomy are particularly challenging: (1) micropick fenestration of the stapes footplate (SF) and (2) crimping of the stapes prosthesis (SP) to the incus. We conducted trials to determine if experience correlates with differences in performance for these tasks.
Methods: In a surgical model of stapedotomy, performance was measured for 3 experienced and 3 novice surgeons. For fenestration, we measured ability to target the fenestration and force applied to the SF. For crimping, we measured crimp quality, movement of the SP during crimping, and force applied to the SF.
Results: Experienced surgeons demonstrated significantly better ability to target the fenestration and, during crimping, caused less SP movement and a significantly lower rate of SP dislodgment.
Conclusions: Clear differences in task performance are measurable between more and less experienced surgeons during critical steps of stapedotomy.
Clinical Significance: The observed differences in task performance may contribute to an understanding of maneuvers that increase the risk of inadequate prosthesis placement and cochlear trauma-factors likely responsible for variable hearing results with strapedotomy.
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http://dx.doi.org/10.1067/mhn.2003.13 | DOI Listing |
Med Phys
December 2024
Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, China.
Background: Medical imaging plays a pivotal role in the real-time monitoring of patients during the diagnostic and therapeutic processes. However, in clinical scenarios, the acquisition of multi-modal imaging protocols is often impeded by a number of factors, including time and economic costs, the cooperation willingness of patients, imaging quality, and even safety concerns.
Purpose: We proposed a learning-based medical image synthesis method to simplify the acquisition of multi-contrast MRI.
Anal Chem
December 2024
MOBILion Systems, Chadds Ford, Pennsylvania 19317, United States.
Rapid identification of asparagine (Asn) deamidation and isoaspartate (Asp) in proteins remains a challenging analytical task during the development of biological therapeutics. For this study, 46 therapeutically relevant peptides corresponding to 13 peptide families (13 unmodified peptides and 33 modified peptides) were obtained; modified peptides included Asn deamidation and isoAsp. The peptide families were characterized by three methods: reversed-phase ultrahigh performance liquid chromatography-mass spectrometry (RP-UHPLC-MS); flow injection analysis high-resolution ion mobility-mass spectrometry (FIA-HRIM-MS); and shortened gradient RP-UHPLC-HRIM-MS.
View Article and Find Full Text PDFAdv Mater
December 2024
School of Materials Science and Engineering, Zhengzhou University, Zhengzhou, 450001, China.
The alkaline oxygen evolution reaction (OER) mainly encompasses four elementary reactions, involving intermediates such as HO*, O*, and HOO*. Balancing the Gibbs free energies of these intermediates at a single active site is a challenging task. In this work, a high-entropy metal-organic framework incorporating Fe, Ni, Co, Cu, and Y metal elements is synthesized using an electrodeposition method, which then serves as a template for preparing a high-entropy phosphide/carbon (FeCoNiCuYP/C) composite.
View Article and Find Full Text PDFChem Sci
December 2024
AI Lab, School of Engineering, Westlake University Hangzhou 310024 Zhejiang China
Generating molecules that bind to specific proteins is an important but challenging task in drug discovery. Most previous works typically generate atoms autoregressively, with element types and 3D coordinates of atoms generated one by one. However, in real-world molecular systems, interactions among atoms are global, spanning the entire molecule, leading to pair-coupled energy function among atoms.
View Article and Find Full Text PDFACS Omega
December 2024
School of Materials Science and Engineering, Zhengzhou University, Zhengzhou, Henan 450001, P. R. China.
The development of conductive hydrogels has garnered significant attention in the field of wearable devices and smart sensors. However, the fabrication of hydrogels that possess both multifunctionality and structural stability remains a challenging task. In this study, a novel hydrogel, PHCB, was synthesized using a mild method and exhibited outstanding characteristics such as electrical conductivity, self-healing capability, antimicrobial activity, dimensional stability, and temperature sensitivity.
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