Several authors have suggested that chaos theory, the study of nonlinear dynamics and the application of the knowledge gained to natural and social phenomena, might yield insight into substance-related disorders. In this article, we examine the dynamics of substance abuse by fitting a nonlinear model to a time series of the amount of alcohol, which an adult male with a diagnosis of substance abuse consumed on a daily basis. The nonlinear model shows a statistically superior fit when compared to a linear model. We then use the model to explore a question that is pertinent to the treatment of substance abuse, whether controlled drinking or abstinence is a preferred strategy for maintaining sobriety.
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http://dx.doi.org/10.1016/s0306-4603(01)00234-9 | DOI Listing |
J Med Chem
January 2025
State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun 130062, China.
To date, the abuse of antibiotics and a gradual decline in novel antibiotic discovery enlarge the threat of drug-resistant bacterial infections, especially methicillin-resistant (MRSA). Herein, inspired by the unique structures and antibacterial activities of 2-quinolones, a class of novel 2-quinolones with substituted pyridines was synthesized. Notably, compound , the derivative with a methylpyridine fragment, showed potent antibacterial and antibiofilm activities, especially for MRSA strains (MIC = 0.
View Article and Find Full Text PDFElife
January 2025
Department of Pharmaceutical Sciences, University of Kentucky, Lexington, United States.
Reversing opioid overdoses in rats using a drug that does not enter the brain prevents the sudden and severe withdrawal symptoms associated with therapeutics that target the central nervous system.
View Article and Find Full Text PDFJ Am Podiatr Med Assoc
January 2025
*University of Texas Southwestern Medical Center, Department of Plastic Surgery, Dallas, TX.
Musculoskeletal infections are common among people who inject drugs. Little is known about the prevalence and characteristics of skin and soft-tissue infections in this patient population, especially in the lower extremity. The aim of this study is to describe the clinical characteristics, bacterial pathogens, and clinical outcomes in adults with foot infections due to intravenous drug use.
View Article and Find Full Text PDFMatern Child Health J
January 2025
Department of Psychology, College of Arts and Sciences, Lehigh University, Bethlehem, USA.
Background: Research has increasingly explored maternal resilience or protective factors that enable women to achieve healthier maternal and child outcomes. However, it has not adequately examined maternal resilience using a culturally-relevant, socio-ecological lens or how it may be influenced by early-life stressors and resources. The current study contributes to the literature on maternal resilience by qualitatively exploring the salient multi-level stressors and resources experienced over the lifecourse by predominantly low-income and minoritized women.
View Article and Find Full Text PDFAm J Forensic Med Pathol
January 2025
From the Department of Pathology, University of Michigan, Ann Arbor, MI.
Pedestrian and bicyclist fatalities have increased over the past decade in the United States. Factors proposed to explain this increase include the increased popularity of larger passenger vehicles, road design to accommodate faster-moving traffic, and poor road infrastructure. We analyzed a series of 102 pedestrian and bicyclist fatalities to determine which factors were involved.
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