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3D-Printed Prosthesis with an Articular Interface for Anatomical Acetabular Reconstruction After Type I + II (+ III) Internal Hemipelvectomy: Clinical Outcomes and Finite Element Analysis.
J Bone Joint Surg Am
October 2024
Musculoskeletal Tumor Center, Department of Orthopedics, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.
Background: Pelvic reconstruction after type I + II (or type I + II + III) internal hemipelvectomy with extensive ilium removal is a great challenge. In an attempt to anatomically reconstruct the hip rotation center (HRC) and achieve a low mechanical failure rate, a custom-made, 3D-printed prosthesis with a porous articular interface was developed. The aim of this study was to investigate the clinical outcomes of patients treated with this prosthesis.
View Article and Find Full Text PDFHigh-throughput proliferation and activation of NK-92MI cell spheroids via a homemade one-step closed bioreactor in pseudostatic cultures for immunocellular therapy.
J Biol Eng
November 2024
Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, No. 35, Keyan Road, Zhunan, Miaoli, 35053, Taiwan.
Article Synopsis
- * A custom bioreactor was developed to create optimal culture conditions by using brief mechanical rotation to foster better aggregate sizes and improve cell viability, achieving a notable 144-fold increase in cell proliferation.
- * After 14 days, the NK-92MI cells retained their characteristics and displayed increased IFN-γ expression following IL-18 activation, enhancing their ability to target cancer cells effectively, indicating a valuable method for advancing immunocellular therapies.
Influence of Continuous Rotation and Optimal Torque Reverse Kinematics on the Cyclic Fatigue Strength of Endodontic NiTi Clockwise Cutting Rotary Instruments.
Dent J (Basel)
September 2024
Dental Specialty Center, Brazilian Military Police, Belo Horizonte 30350-190, Brazil.
Article Synopsis
- The study aimed to assess the cyclic fatigue strength of rotary endodontic instruments using two different movement techniques: continuous clockwise rotation and clockwise reciprocation with optimum torque reverse (OTR) motion.
- ProTaper Next X1 and X2 instruments were tested in a standard artificial canal, with the results showing that OTR movement significantly increased the time to fracture compared to continuous rotation.
- Although both instrument types displayed signs of cyclic fatigue failure, the OTR motion appeared to improve instrument longevity by evenly distributing mechanical stress, leading to a delay in catastrophic failure.
Fluorescence Immunoassay of Prostate-Specific Antigen Using 3D Paddle Screw-Type Devices and Their Rotating System.
Biosensors (Basel)
October 2024
Department of Pharmaceutical Engineering, Soonchunhyang University, Asan 31538, Republic of Korea.
In this paper, we present a sensitive and highly reproducible fluorescence immunosensor for detecting PSA in human serum. A unique feature of this study is that it uses creatively designed paddle screw-type devices and their custom-made rotating system for PSA immunoassay. The paddle screw devices were designed to maximize the surface-to-volume ratio over which the immunoassay reaction could occur to improve detection sensitivity.
View Article and Find Full Text PDFRationally designed acoustic holograms for uniform nanodroplet-mediated tissue ablation.
IEEE Trans Ultrason Ferroelectr Freq Control
October 2024
Nanodroplets are phase-changing agents that have shown great potential for ultrasound applications. When ultrasound is applied, nanodroplets can undergo a phase transition into gas bubbles, enabling cavitation that can be used to reduce the pressure threshold required for mechanical ablation of tissues. Effective tissue fractionation depends on precise vaporization to achieve uniform and predictable bubble formation.
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