AI Article Synopsis
- The study aimed to evaluate how immunization with recombinant 26 kDa glutathione-S-transferase (reSjc26GST) affects antibody response and protection against Schistosoma japonicum infections in buffaloes.
- In the experiment, 96 buffaloes were vaccinated, while 90 served as a control group without vaccination; the researchers measured antibody levels before and after infection and analyzed infection rates.
- Results showed a significant increase in specific antibodies post-immunization and a 62.2% reduction in infection rates in the vaccinated group compared to pre-vaccination and a 67.7% reduction compared to the control group, indicating the vaccine's effectiveness in reducing morbidity.
Article Abstract
Objective: To observe the dynamics of antibodies and protection against Schistosoma japonicum infections in buffaloes after immunized with recombinant 26 kDa glutathione-S-transferase (reSjc26GST).
Methods: Buffaloes in 2 villages endemic for schistosomiasis japonica were selected as test and control groups, respectively. In test group initially 96 buffaloes were vaccinated with reSjc26GST, and 90 buffaloes in the control group did not experience vaccination. The indicators included levels of antibodies to reSjc26GST in buffaloes before and after infection with S. japonicum and changes in infection rate.
Results: Specific antibodies, which showed a trend of trapezoid increase, were induced in buffaloes after immunized with reSjc26GST. Twenty months after immunization, the infection rate of the test group was decreased by 62.2% when compared with that before vaccination, and by 67.7% when compared with that of the control in the corresponding period.
Conclusion: Specific antibodies and a certain extent of protection were induced in buffaloes after immunized with reSjc26GST, which played an significant role in ameliorating morbidity.
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