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Olive Fruit Phenolic Profiling Using High Resolution-Magic Angle Spinning (HR-MAS) Solid-State NMR Spectroscopy.
Methods Mol Biol
January 2025
NMR Laboratory, Chemistry Department, University of Crete, Heraklion, Crete, Greece.
High Resolution-Magic Angle Spinning (HR-MAS) solid-state NMR spectroscopy is finding increasing application in the analysis of solid foods, bypassing the need for complicated solvent extraction procedures. In the present protocol, we report a simple analytical approach based on HR-MAS NMR spectroscopy for the phenolic profiling of olive fruits, flesh, or skin. This approach allows the facile characterization of phenolic compounds in olive fruits cultivated for extra-virgin olive oil production as a function of maturation and variety, in addition to processing technology for table olives.
View Article and Find Full Text PDFHyaluronic acid-based hydrogels as codelivery systems: The effect of intermolecular interactions investigated by HR-MAS and solid-state NMR Spectroscopy.
Carbohydr Polym
February 2025
Dipartimento di Chimica, Materiali e Ingegneria Chimica "G. Natta", Politecnico di Milano, via Mancinelli 7, I-20131 Milano, MI, Italy. Electronic address:
Article Synopsis
- - Hydrogels made from hyaluronic acid and agarose-carbomer are being studied for their potential to simultaneously deliver multiple drugs for different diseases, thanks to their biocompatibility and unique 3D structure.
- - The study focuses on how ethosuximide and sodium salicylate interact and diffuse within these hydrogels, using advanced techniques like NMR Spectroscopy to analyze their transport properties.
- - Findings suggest that when both drugs are loaded together, they behave similarly in their diffusion patterns, which may be influenced by drug-drug interactions, leading to a proposed trapping-release mechanism that affects how the drugs are released from the hydrogels.
MYC-dependent upregulation of the de novo serine and glycine synthesis pathway is a targetable metabolic vulnerability in group 3 medulloblastoma.
Neuro Oncol
January 2025
Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Newcastle Upon Tyne, UK.
Article Synopsis
- Group 3 medulloblastoma (MBGRP3) is a type of brain cancer that's linked to the MYC gene, which makes it harder for patients to recover.
- Researchers are exploring ways to target MYC by studying how it affects certain chemical processes in cells.
- The study found that blocking a specific enzyme related to the MYC pathway could help increase survival in mouse models, suggesting new ways to treat this serious form of cancer.
HRMAS H NMR and CPMAS C NMR spectroscopies coupled with chemometrics for the metabolomic investigation of commercial teas.
Food Chem
December 2024
Department of Agricultural, Food and Forest Sciences, University of Palermo, v.le delle Scienze ed. 4, 90128 Palermo, Italy.
In this study, the metabolome of different types of tea (i.e., black, green and earl grey) is explored by means of HRMAS H (i.
View Article and Find Full Text PDFPreparation of Single-Helical Curdlan Hydrogel and Its Activation with Coagulation Factor G.
Polymers (Basel)
May 2024
Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan 430071, China.
β-1,3-glucans are a kind of natural polysaccharide with immunomodulatory, antitumor, and anti-inflammatory properties. Curdlan, as the simplest linear β-1,3-glucan, possesses a variety of biological activities and thermogelation properties. However, due to the complexity and variability of the conformations of curdlan, the exact structure-activity relationship remains unclear.
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