The search for "reversible causes" in the patient presenting with dementia has become a routine part of medical care. This article reviews evidence as to the prevalence of reversibility and concludes that actual reversal of dementia by treatment is rare. In this context, the utility of specific laboratory investigations is discussed, and commonly sought conditions, such as normal-pressure hydrocephalus and B12 deficiency, are reviewed. Overemphasis on reversibility risks neglect of the assistance physicians can provide to patients suffering from irreversible conditions and their families.
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http://dx.doi.org/10.1053/scnp.2003.50003 | DOI Listing |
Drugs
January 2025
Division of Endocrinology, Department of Pediatrics, College of Medicine, University of Florida, 1699 SW 16th Ave, Building A, Gainesville, FL, 32608, USA.
Type 1 diabetes mellitus (T1DM) is characterized by the progressive, autoimmune-mediated destruction of β cells. As such, restoring immunoregulation early in the disease course is sought to retain endogenous insulin production. Nevertheless, in the more than 100 years since the discovery of insulin, treatment of T1DM has focused primarily on hormone replacement and glucose monitoring.
View Article and Find Full Text PDFBrain Sci
January 2025
Department of Biological Sciences, Faculty of Science, Yarmouk University, Irbid 21163, Jordan.
Background: Tramadol (TRA) is an opioid that is used to manage moderate to severe pain. Long-term use of TRA can lead to the development of opioid use disorder.
Objectives: This study investigates the role of forced exercise in reducing TRA-seeking behavior.
Int Immunopharmacol
January 2025
Xinjiang Key Laboratory of Cardiac Electrophysiology and Remodeling, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China; Department of Pacing and Electrophysiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China. Electronic address:
Background: The antiarrhythmic effect of melatonin(MLT) has been demonstrated in several studies; however, this hypothesis has recently been contested. Our research seeks to determine if exogenous MLT supplementation can reduce atrial fibrillation (AF) susceptibility due to sleep deprivation (SD) by addressing Ca mishandling and atrial mitochondrial oxidative stress.
Methods: Adult rats received daily MLT or vehicle injections and were exposed to a modified water tank.
RSC Adv
January 2025
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University No. 100, Shih-Chuan 1st Road, Sanmin District Kaohsiung City 80708 Taiwan.
Cancer is a leading global health concern, with over 20 million new cases and 9.7 million deaths reported in 2022. Chemotherapy remains a widely used treatment, but drug resistance, which affects up to 90% of treatment outcomes, significantly hampers its effectiveness.
View Article and Find Full Text PDFBMC Public Health
January 2025
Division of Epidemiology, School of Public Health, Tohoku University Graduate School of Medicine, 2-1 Seiryo-Machi, Aoba-Ku, Sendai-Shi, Miyagi, 980-0872, Japan.
Background: Informal caring is associated with mental health deterioration among young people and impacts their help-seeking ability. Social network can provide social support and mitigate the impact of informal care. However, young carers may avoid identification and withdraw from social networks.
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