The evolution of therapy for malignant ovarian germ cell tumors is one of the true success stories in oncology. Treatment outcome has improved greatly thanks to cisplatin-based combination chemotherapy. According to the well-established treatment guidelines for advanced cases, we treated a case of stage IV undifferentiated germ cell tumor in which we were able to preserve the patient's fertility. We concluded that the PEP regimen is an effective treatment for the patient with metastatic germ cell tumor.
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http://dx.doi.org/10.1159/000067716 | DOI Listing |
Commun Biol
December 2024
Shanghai Tenth People's Hospital, Institute for Infectious Diseases and Vaccine Development, School of Medicine, Tongji University, Shanghai, China.
Adult Schistosoma produces a large number of eggs that play essential roles in host pathology and disease dissemination. Consequently, understanding the mechanisms of sexual maturation and egg production may open a new avenue for controlling schistosomiasis. Here, we describe that Bantam miRNA and miR-1989 regulate Wnt signaling pathway by targeting Frizzled-5/7/9, which is involved in ovarian development and oviposition.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
State Key Laboratory of Swine and Poultry Breeding Industry & Guangdong Key Laboratory of Animal Breeding and Nutrition & Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China. Electronic address:
The faithful production of primordial germ cells (PGCs) in vitro opens a wide range of novel applications in reproductive biology and medicine. However, the reproducibility of PGCs culture conditions across different laboratories or breeds remains a challenge. Therefore, it is necessary to research the molecular dynamics that lead to the gradual establishment of cultured PGCs lines network.
View Article and Find Full Text PDFTrop Anim Health Prod
December 2024
Animal Nutrition Laboratory, Department of Animal Production and Health, School of Agriculture and Agricultural Technology, The Federal University of Technology Akure, P.M.B. 704, Akure, Nigeria.
To assess the ameliorative effects of wireweed leaf supplement (WLS) and ascorbate on reproductive potentials and gonadal oxidative status of cocks fed aflatoxin B1 (AFB1) contaminated diets, a total of 250 sexually mature cocks were distributed into five treatment groups: 1 (Control/Basal diet), 2 (Basal + 1 mg/kg AFB1), 3 (Basal + 1 mg/kg AFB1 + 200 mg/kg Ascorbate), 4 (Basal + 1 mg/kg AFB1 + 2.50 g/kg WLS) and 5 (Basal + 1 mg/kg AFB1 + 5.00 g/kg WLS).
View Article and Find Full Text PDFSci Rep
December 2024
Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.
Excessive production of reactive oxygen species (ROS) during cryopreservation and post-thawing affects sperm quality and subsequent fertilizing capacity. Nanoparticles (NPs) with antioxidative properties can improve sperm function and male fertility. The aim of this study was to assess the effect of 100 µM ρ-coumaric acid (ρ-CA), 0.
View Article and Find Full Text PDFSci Rep
December 2024
School of Biosciences, University of Kent, Canterbury, Kent, CT2 7NZ, UK.
Worldwide museums hold collections of eggshells representing material for descriptive studies. However, an obstacle to this is the lack of information about the original contents and weight of the entire egg (W). This study aimed to fill this gap though development of a methodological mechanism for calculating the volume of the egg interior (V), its density (D) and W.
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