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Organic phenyl arsonic acid compounds with potent antileukemic activity. | LitMetric

Organic phenyl arsonic acid compounds with potent antileukemic activity.

Bioorg Med Chem Lett

Parker Hughes Cancer Center, Parker Hughes Institute, 2699 Patton Road, St. Paul, MN 55113, USA.

Published: February 2003

AI Article Synopsis

Article Abstract

A series of 12 organic arsonic acid compounds has been synthesized and evaluated against human B-lineage (NALM-6) and T-lineage (MOLT-3) acute lymphoblastic leukemia (ALL) cell lines. The lead compounds 2-trichloromethyl-4-[4'-(4"-phenylazo)phenylarsonic acid]aminoquinazoline (compound 19, PHI-P518; IC(50)=1.1+/-0.5 microM against NALM-6 and 2.0+/-0.8 microM against MOLT-3) and 2-methylthio-4-(2'-phenylarsonic acid)aminopyrimidine (compound 15, PHI-P381; IC(50)=1.5+/-0.3 microM against NALM-6 and 2.3+/-0.5 microM against MOLT-3) exhibited potent antileukemic activity at low micromolar concentrations.

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Source
http://dx.doi.org/10.1016/s0960-894x(02)00928-9DOI Listing

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