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Phospholipid Bilayer Properties in pH-Responsive Hemoglobin-Based Oxygen Carriers.
J Phys Chem B
March 2025
Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Texas 78712, United States.
Hemoglobin (Hb)-based oxygen carriers (HBOCs) are a potential solution to the growing shortage in the worldwide blood supply. Recent developments in HBOC design have shown that Polyethylene glycol surface-conjugated liposome-encapsulated Hb (PEG-LEH) has shown promising results in mimicking the oxygen uptake and release of human red blood cells. This study aims to use atomistic simulations to investigate the mechanical properties, gas-exchange properties, and pH responsiveness of a novel HBOC which introduces a pH-sensitive molecule (KC1003) to the phospholipid membrane to regulate the uptake and release of oxygen based on pH.
View Article and Find Full Text PDFSolid-State NMR of Virus Membrane Proteins.
Acc Chem Res
February 2025
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
ConspectusEnveloped viruses encode ion-conducting pores that permeabilize the host cell membranes and mediate the budding of new viruses. These viroporins are some of the essential membrane proteins of viruses, and have high sequence conservation, making them important targets of antiviral drugs. High-resolution structures of viroporins are challenging to determine by X-ray crystallography and cryoelectron microscopy, because these proteins are small, hydrophobic, and prone to induce membrane curvature.
View Article and Find Full Text PDFRecombinant-Chemosynthetic Biosensors for Probing Cell Surface Signaling of Red Blood Cells and Other Cells.
Chem Biomed Imaging
February 2025
Department of Chemistry, Saint Louis University, Saint Louis, Missouri 63103, United States.
The complex signaling mechanisms in red blood cells (RBCs) enable them to adapt to physiological stresses such as exposure to low O levels, metabolic demands, oxidative stress, and shear stress. Since Ca is a crucial determinant of RBC fate, various ion channels, pumps, and exchangers regulate the delicate balance of Ca influx and efflux in RBCs. Elevated intracellular Ca can activate processes such as membrane phospholipid scrambling and alter RBC deformability, which is essential for effective capillary transit.
View Article and Find Full Text PDFHepatic lipid metabolism is altered in Ubiad1 mice of both sexes.
Sci Rep
February 2025
Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Sognsvannsveien 9, Domus Medica, 0372 Oslo, Norway.
UbiA prenyltransferase domain containing 1 (Ubiad1) has the potential to affect cholesterol and phospholipid levels in different cell types. We previously identified Ubiad1 as a candidate gene for regulating subcutaneous fat pad weight in a mouse genome-wide association study. Here we evaluated the relationship between Ubiad1 and obesity-related traits in cohorts of humans and mice, and in Ubiad1 mice fed a high-fat diet.
View Article and Find Full Text PDFInsights from lipidomics into the terminal maturation of circulating human reticulocytes.
Cell Death Discov
February 2025
Dynamics of Fluids, Experimental Physics, Saarland University, Saarbrücken, Germany.
In the age of "omics", lipidomics of erythropoiesis is still missing. How reticulocytes mature in the circulation into functional erythrocytes is also largely unknown. We have isolated here two populations of human circulating reticulocytes at different levels of maturation, and three subpopulations of erythrocytes of different age, and characterized the evolution of their lipidome.
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