AI Article Synopsis
- The study examined the stability of neuropsychological impairment in first episode schizophrenia by comparing 50 patients with 50 healthy controls over two years.
- The results showed that while verbal learning (VBL) improved, other cognitive functions like semantic memory (SEM) and visual-motor processing (VSM) remained stable, with visual memory (VIM) showing no improvement.
- Findings suggest that there is no evidence of progressive deterioration in neuropsychological functioning in the initial years of schizophrenia, contradicting some assumptions about the illness.
Article Abstract
To investigate the temporal stability, or progressivity, of neuropsychological (NP) impairment in schizophrenia, 50 patients with first episode (FE) schizophrenia and 50 healthy controls were given a battery of tests at the outset of the study and after a two-year interval. Both patient and control groups were balanced with respect to age, gender, education and parental socioeconomic status. Summary rating scales for semantic memory (SEM), visual memory (VIM), verbal learning (VBL), visual-motor processing and attention (VSM) and abstraction/flexibility (ABS) were constructed. FE schizophrenics showed improvement in VBL, stability of function in SEM, VSM and ABS and absence of improvement in VIM. While performance in VSM and VIM is influenced by medication status, SEM seems to be trait-related and stable; VBL, however, seems to be state-related. Our data suggest that there is no proof for the assumption of progressive deterioration in NP functioning during the first few years of illness.
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| http://dx.doi.org/10.1007/s00406-002-0391-4 | DOI Listing |
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