AI Article Synopsis
- A newly discovered group of cytoplasmic proteins called NALPs plays a crucial role in activating caspase-1 when the cell responds to microbial infections via Toll-like receptors (TLRs).
- NALP1, similar to APAF-1 which activates caspase-9, forms a large protein complex known as the inflammasome.
- This inflammasome leads to the activation of pro-inflammatory caspases, which are essential for the inflammatory response in cells.
Article Abstract
A newly discovered family of cytoplasmic proteins--the NALPs--has been implicated in the activation of caspase-1 by the Toll-like receptors (TLRs) during the cell's response to microbial infection. Like the structurally related apoptotic protease-activating factor-1 (APAF-1), which is responsible for the activation of caspase-9, the NALP1 protein forms a large, signal-induced multiprotein complex, the inflammasome, resulting in the activation of pro-inflammatory caspases.
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| http://dx.doi.org/10.1038/nrm1019 | DOI Listing |
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