The hypotensive effect of manascus was studied by using three well established rat models with hypertension: spontaneously hypertensive rat (SHR), renalvascular hypertensive rat (RHR, 2K1C) and DOCA-salt hypertensive rat. Manascus of 0.0, 0.4, 0.8, 1.2 g/kg BW (p.o.) were administrated daily to these animals for 3-4 weeks. Systolic blood pressure (SBP) and heart rate were measured once a week by using tail-cuff method. The hypotensive effect of manascus was observed in SHR and DOCA-salt hypertensive rats; and the effect was more potent in DOCA-salt hypertensive rat. Manascus showed less potential hypotensive effect in RHR.
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