We report a case of a locally advanced verrucous scrotal cancer in a patient with hypospadias. Surgical excision was performed and no recurrence was noted with 14 months of follow-up. To our knowledge, this association has not been reported. Historically, scrotal carcinoma is occupation related, but none of the occupational predisposing factors was identified in this patient. This observation suggests that hypospadias and secondary chronic inflammation of the scrotal skin, caused by prolonged contact with urine, may contribute to an increased risk of verrucous carcinoma.
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- Scrotal squamous cell carcinomas (SCCs) are rare cancers previously thought not to be linked to HPV, but recent studies show evidence of HPV presence in these tumors.
- A study examined scrotal SCC cases from cancer registries using tissue samples and HPV testing, confirming the morphology of the tumors.
- Out of five identified cases, two were HPV-positive (HPV16) with p16 overexpression, suggesting a potential link between HPV and the development of scrotal SCC.
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