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Clinical Manifestations.
Alzheimers Dement
December 2024
John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Background: Over 13,000 individuals from both domestic and African sites will be collected for the READD-ADSP study. Adjudicating this number of individuals is challenging, so we evaluated knowledge-based decision tree algorithms to predict clinical diagnoses using nationally representative norms and standard cut-offs. Additional models were constructed using culturally adjusted cut-offs, domain average cut-offs, and exclusion of the Trail Making Test (TMT) which performed poorly.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
CBI en Demencias y Enfermedades Desmielinizantes del Sistema Nervioso, Instituto Nacional de Ciencias Neurológicas, Lima, Peru.
Background: Early-onset Alzheimer's disease (EOAD) is a rare and devasting form of Alzheimer disease that represents 5-10% of the total number of Alzheimer disease (AD). It is significantly less well studied than the late-onset form of AD. The clinical presentation is heterogeneous, the amnestic variant is the most frequent (75%).
View Article and Find Full Text PDFBeyond Seizures: Psychiatric comorbidities in children with epilepsy.
Epilepsy Behav
December 2024
Department of Neurology, American University of Beirut Medical Center, Beirut, Lebanon. Electronic address:
Purpose: Children with epilepsy are at an increased risk of developing psychiatric comorbidities, which exacerbate the overall disease burden. However, these disorders are often underreported in developing countries. This study, conducted in a developing country, aims to evaluate the frequency of psychiatric disorders and associated factors in a large cohort of children with epilepsy.
View Article and Find Full Text PDFPrevalence of dementia among Indigenous populations of countries with a very high Human Development Index: a systematic review.
Lancet Healthy Longev
December 2024
School of Translational Medicine, Monash University, Melbourne, VIC, Australia; Faculty of Medicine, Dentistry, and Health Sciences, The University of Melbourne, Melbourne, VIC, Australia.
Dementia is a health priority for Indigenous peoples. Here, we reviewed studies on the prevalence of dementia or cognitive impairment among Indigenous populations from countries with a very high Human Development Index (≥0·8). Quality was assessed using the Joanna Briggs Institute risk-of-bias tool and CONSolIDated critERia for strengthening the reporting of health research involving Indigenous peoples (CONSIDER), with oversight provided by an Indigenous Advisory Board.
View Article and Find Full Text PDFRobert Wartenberg and the Hallervorden Affair, 1953: A Clash Between Medical Ethics and Cold War Politics.
Neurology
January 2025
Department of Neurology, Henry Ford Health, Detroit, MI; and.
Robert Wartenberg was an emigrant from Nazi Germany and an iconic pioneer in neurology, describing eponyms and helping to found and nurture the American Academy of Neurology. However, in 1953, ironically, he became embroiled in a controversial event regarding the German neuroscientist and Nazi collaborator Julius Hallervorden. Wartenberg attempted to convince the Dutch delegation to attend the International Neurological Congress in Lisbon from which they had withdrawn in response to Hallervorden's inclusion as a speaker.
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