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Why is the prevailing model of joint manipulation (still) incorrect?
Chiropr Man Therap
December 2022
Centre of Precision Rehabilitation for Spinal Pain, School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Article Synopsis
- The paper critiques the Sandoz model of joint manipulation, arguing it is fundamentally flawed and misleading for clinical practice.
- It reviews the early research on joint cracking that misinformed this model and highlights the potential dangers of its flawed predictions.
- A revised model from Evans and Breen is proposed as a better alternative, aligning with empirical data and suggesting the need for an updated definition of manipulation in therapy.
Body dysmorphic disorder: a treatment synthesis and consensus on behalf of the International College of Obsessive-Compulsive Spectrum Disorders and the Obsessive Compulsive and Related Disorders Network of the European College of Neuropsychopharmacology.
Int Clin Psychopharmacol
March 2021
Department of Clinical and Pharmaceutical Sciences, University of Hertfordshire and Hertfordshire Partnership University NHS Foundation Trust, Hatfield, UK.
Body dysmorphic disorder (BDD) is characterized by a preoccupation with a perceived appearance flaw or flaws that are not observable to others. BDD is associated with distress and impairment of functioning. Psychiatric comorbidities, including depression, social anxiety, and obsessive-compulsive disorder are common and impact treatment.
View Article and Find Full Text PDFThe real "danger" lies in the failure to confront fundamentals.
Scand J Immunol
December 2018
Conceptual Immunology Group, The Salk Institute, La Jolla, California.
Can we formulate a framework that would provide an agreed upon basis for discussions of immune behaviour? An attempt to do this is, in the end, the main goal of this essay. If you tell a physicist that you have invented a perpetual motion machine, he would not spend any time trying to reveal the flaw. Rather, he would shrug you off because in his framework, such a machine is an impossibility.
View Article and Find Full Text PDFPhysiological Roles and Adverse Effects of the Two Cystine Importers of Escherichia coli.
J Bacteriol
December 2015
Department of Microbiology, University of Illinois, Urbana, Illinois, USA
Unlabelled: When cystine is added to Escherichia coli, the bacterium becomes remarkably sensitive to hydrogen peroxide. This effect is due to enlarged intracellular pools of cysteine, which can drive Fenton chemistry. Genetic analysis linked the sensitivity to YdjN, a secondary transporter that along with the FliY-YecSC ABC system is responsible for cystine uptake.
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