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Hypertension and obesity independently drive hypertrophy and alter mitochondrial metabolism in a mouse model of heart failure with preserved ejection fraction.
Physiol Rep
September 2024
Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, USA.
Heart failure with preserved ejection fraction (HFpEF) has recently emerged as an insidiously and increasingly prevalent heart failure phenotype. HFpEF often occurs in the context of hypertension and obesity and presents with diastolic dysfunction, ventricular hypertrophy, and myocardial fibrosis. Despite growing study of HFpEF, the causal links between early metabolic changes, bioenergetic perturbations, and cardiac structural remodeling remain unclear.
View Article and Find Full Text PDFProgressive lung fibrosis: reprogramming a genetically vulnerable bronchoalveolar epithelium.
J Clin Invest
January 2025
Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Article Synopsis
- IPF development involves a two-hit process: an initial vulnerability of the lung's epithelial cells followed by a second injury that triggers fibrotic changes.
- Genetic factors play a crucial role in the first hit, while ongoing damage disrupts normal cell function and activates fibroblasts, leading to lung fibrosis.
- Understanding IPF in terms of its stages may lead to new treatments that target these underlying causes, aiming for a shift from palliative care to potential cures for patients.
Two Hits of EDCs Three Generations Apart: Evaluating Multigenerational Anxiety-Like Behavioral Phenotypes in Male Rats Exposed to Aroclor 1221 and Vinclozolin.
Environ Health Perspect
December 2024
Division of Pharmacology & Toxicology, The University of Texas at Austin, Austin, Texas, USA.
Background: Increasing evidence supports an association of endocrine-disrupting chemical (EDC) exposures with adverse biological effects in humans and wildlife. Recent studies reveal that health consequences of environmental exposures may persist or emerge across generations. This creates a dual conundrum: that we are exposed to contemporary environmental chemicals overlaid upon the inheritance of our ancestors' exposure profiles.
View Article and Find Full Text PDFTwo Hits of EDCs Three Generations Apart: Evaluating Multigenerational Anxiety-Like Behavioral Phenotypes in Female Rats Exposed to Aroclor 1221 and Vinclozolin.
Environ Health Perspect
December 2024
Division of Pharmacology & Toxicology, The University of Texas at Austin, Austin, Texas, USA.
Background: Endocrine-disrupting chemicals (EDCs) are exogenous chemical compounds that interfere with the normal function of the endocrine system and are linked to direct and inherited adverse effects in both humans and wildlife. Legacy EDCs such as polychlorinated biphenyls (PCBs) are no longer used yet remain detectable in biological specimens around the world; concurrently, we are exposed to newer EDCs like the fungicide vinclozolin (VIN). This combination of individuals' direct environmental chemical exposures and any heritable changes caused by their ancestors' chemical exposures leads to a layered pattern of both direct and ancestrally inherited exposures that might have cumulative effects over generations.
View Article and Find Full Text PDFHarnessing computational and experimental approaches to identify potent hits against Leishmania donovani sterol C-24 methyltransferase from ChemBridge library.
Acta Trop
December 2024
Infectious Diseases Division, CSIR- Indian Institute of Integrative Medicine, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address:
Leishmaniasis is a neglected tropical disease and is one of the major causes of mortality in poverty-stricken areas. A limited chemotherapeutics arsenal is available to tackle this deadly infection. Thus, identifying novel potent scaffolds using innovative strategies is the need of the hour.
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