AI Article Synopsis
- P-Glycoprotein is crucial for transporting toxic lipophilic cationic compounds from liver cells to bile and is found in bile canaliculi.
- This study investigates the expression of P-Glycoprotein in various liver disease models, including acute paracetamol poisoning and cholestasis.
- Results showed that the expression of mdr1b increased in liver disease models compared to controls, while mdr2 levels remained unchanged across different conditions.
Article Abstract
Excretion of lipophilic cationic toxic compounds from the interior of the hepatocyte to the bile is mediated by P-Glycoprotein. It is an integral protein located in the bile canaliculi. The present work study the hepatic expression of P-Glycoprotein in different models of experimental liver disease: Acute paracetamol intoxication, extrahepatic cholestasis and cholestasis followed by acute paracetamol intoxication. mRNA was isolated from liver tissue, and the expression of Pg-p was assessed by Northern blot. It is concluded that the hepatic expression of mdr1b is increased in the experimental liver diseases when compared to controls. On the other hand, mdr2 expression was similar between the different groups.
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