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Harvest of Vestibular End-Organs under Physiologic Conditions during Labyrinthectomy.
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Department of Otolaryngology - Head & Neck Surgery, Johns Hopkins University School of Medicine.
The living human inner ear is challenging to study because it is encased within dense otic capsule bone that limits access to biological tissue. Traditional temporal bone histopathology methods rely on lengthy, expensive decalcification protocols that take 9-10 months and reduce the types of tissue analysis possible due to RNA degradation. There is a critical need to develop methods to access fresh human inner ear tissue to better understand otologic diseases, such as Ménière's disease, at the cellular and molecular level.
View Article and Find Full Text PDFAnalysis and Imaging of Osteocytes.
J Vis Exp
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Department of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City;
Osteocytes are the bone cells that are thought to respond to mechanical strains and fluid flow shear stress (FFSS) by activating various biological pathways in a process known as mechanotransduction. Confocal image-derived models of osteocyte networks are a valuable tool for conducting Computational Fluid Dynamics (CFD) analysis to evaluate shear stresses on the osteocyte membrane, which cannot be determined by direct measurement. Computational modeling using these high-resolution images of the microstructural architecture of bone was used to numerically simulate the mechanical loading exerted on bone and understand the load-induced stimulation of osteocytes.
View Article and Find Full Text PDFAssay Development for High-Throughput Drug Screening Against Mycobacteria.
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i3S - Instituto de Investigação e Inovação em Saúde da Universidade do Porto; ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto;
Mycobacterium abscessus (Mab) infections are challenging to treat due to high intrinsic drug resistance, comparable to multidrug-resistant tuberculosis. Treatments are extremely ineffective and based on a multi-drug regimen, resulting in low patient compliance. Consequently, the scientific community is urged to identify new and effective drugs to treat these infections.
View Article and Find Full Text PDFImpact of General Anesthesia on Ciliary Functional Analysis by Digital High-Speed Videomicroscopy in Suspected Primary Ciliary Dyskinesia.
Diagnostics (Basel)
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Department of ENT, University Hospital Liège, Avenue de l'Hôpital1, 4000 Liège, Belgium.
Digital high-speed videomicroscopy (DHSV) is a crucial tool for evaluating ciliary function in children suspected of primary ciliary dyskinesia (PCD). However, until now, samples are taken without anesthesia due to uncertainty about its effect on ciliary function and DHSV interpretation. This study aimed to investigate the impact of general anesthesia on ciliary functional analysis by DHSV in a series of three patients listed for ENT surgeries, which could improve diagnostic procedures for pediatric patients.
View Article and Find Full Text PDFLabel-Free Non-Contact Vascular Imaging using Photon Absorption Remote Sensing.
IEEE Trans Biomed Eng
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Objective: Functional vascular imaging is a critical method for early detection and prevention of disease. Established non-contact vascular imaging techniques capture predominantly structural information. In this study, a novel non-contact label-free in vivo Photon Absorption Remote Sensing (PARS) microscope is developed for structural and functional vascular imaging.
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