Gabapentin for the treatment of tremor.

Objective: To review the use of the antiepileptic drug gabapentin for the treatment of various types of tremor.

Data Sources: A search of biomedical literature was completed through MEDLINE and EMBASE (1993-May 2002) to identify all clinical trials pertaining to the use of gabapentin for the treatment of tremor in humans.

Data Synthesis: Outcome data from the few published studies have varied widely. Patient groups have been small, and conclusions have been based largely on subjective patient and investigator ratings.

Conclusions: A trial of gabapentin is warranted in patients who fail therapy with traditional agents. Improvement should be measured by a patient's perceived functional ability.