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Emerging trends in pediatric nephrology: A new frontier in care and research.
Pediatr Neonatol
January 2025
Division of Pediatric Nephrology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, 833, Taiwan; College of Medicine, Chang Gung University, Taoyuan, 330, Taiwan; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, 833, Taiwan. Electronic address:
Kidney Programming and Hypertension: Linking Prenatal Development to Adulthood.
Int J Mol Sci
December 2024
Department of Pharmacy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.
The complex relationship between kidney disease and hypertension represents a critical area of research, yet less attention has been devoted to exploring how this connection develops early in life. Various environmental factors during pregnancy and lactation can significantly impact kidney development, potentially leading to kidney programming that results in alterations in both structure and function. This early programming can contribute to adverse long-term kidney outcomes, such as hypertension.
View Article and Find Full Text PDFAntihypertensive Effects of a Sodium Thiosulfate-Loaded Nanoparticle in a Juvenile Chronic Kidney Disease Rat Model.
Antioxidants (Basel)
December 2024
Polymeric Biomaterials Laboratory, Department of Materials and Optoelectronic Science, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.
Sodium thiosulfate (STS), a precursor of hydrogen sulfide (HS), has demonstrated antihypertensive properties. Previous studies have suggested that HS-based interventions can prevent hypertension in pediatric chronic kidney disease (CKD). However, the clinical application of STS is limited by its rapid release and intravenous administration.
View Article and Find Full Text PDFExploring Oxidative Stress and Metabolic Dysregulation in Lung Tissues of Offspring Rats Exposed to Prenatal Polystyrene Microplastics: Effects of Melatonin Treatment.
Antioxidants (Basel)
November 2024
Division of Pediatric Pulmonology, Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, Chang Gung University, Taoyuan 333, Taiwan.
Metabolomics research provides a clearer understanding of an organism's metabolic state and enables a more accurate representation of its functional performance. This study aimed to investigate changes in the metabolome of lung tissues resulting from prenatal exposure to polystyrene microplastics (PS-MPs) and to understand the underlying mechanisms of lung damage in rat offspring. We conducted metabolomic analyses of lung tissue from seven-day-old rat pups exposed to prenatal PS-MPs.
View Article and Find Full Text PDFProtective Effect of Resveratrol on Kidney Disease and Hypertension Against Microplastics Exposure in Male Juvenile Rats.
Antioxidants (Basel)
November 2024
Department of Pharmacy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.
Global pollution stems from the degradation of plastic waste, leading to the generation of microplastics (MPs). While environmental pollutants increase the risk of developing hypertension and kidney disease, the effects of MP exposure on these conditions in children remain unclear. Resveratrol, a phenolic compound known for its antihypertensive and renoprotective properties, has gained attention as a potential nutraceutical.
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