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The effect of polyvinylpyrrolidone-sodium hyaluronate gel (Gelclair) on oral microbial colonization and pain control compared with other rinsing solutions in patients with oral mucositis after allogeneic stem cells transplantation.
Med Sci Monit
October 2011
Department of Haemato-Oncology, University Hospital in Pilsen, Pilsen, Czech Republic.
Background: Gelclair is an oral lubricating gel used in the management of oral mucositis (OM). We evaluated its efficacy, tolerance and impact on oral cavity microbial colonization in patients with OM after allogeneic hematopoietic stem cells transplantation.
Material/method: Gelclair was administered in a group of 22 patients with active OM.
Comparing pain control and ability to eat and drink with standard therapy vs Gelclair: a preliminary, double centre, randomised controlled trial on patients with radiotherapy-induced oral mucositis.
Support Care Cancer
April 2007
RD&E NHS Foundation Trust, Barrack Rd, Exeter, Devon, EX2 5DW, UK.
Unlabelled: GOAL OF THE WORK: Oral mucositis (OM) is a functionally destructive complication of aggressive head and neck cancer therapy, often resulting in intense pain, an inability to eat and drink and secondary malnutrition and dehydration. The barrier-forming properties of Gelclair have shown promise in relieving such symptoms. The aim of this randomised-controlled trial was to evaluate the efficacy of Gelclair, as compared to standard therapy, as a means of short-term symptom control for patients suffering from radiotherapy-induced OM.
View Article and Find Full Text PDFEvaluation of the clinical behaviour of a polyvinylpyrrolidone and sodium hyalonurate gel (Gelclair) in patients subjected to surgical treatment with CO2 laser.
Int J Oral Maxillofac Surg
June 2006
Department of Oral Surgery, Faculty of Dentistry, University of Seville, C/ Avicena s/n 41009, Seville, Spain.
This experimental study was undertaken to evaluate the efficacy of Gelclair, a concentrated oral gel consisting of sodium hyalonurate and polyvinylpyrrolidone, in decreasing postoperative pain in patients subjected to surgical treatment by extirpation and/or vapourization of oral lesions with CO(2) laser. After the surgery, 60 consecutive patients (30 in control group and 30 in experimental group) were prescribed 600 mg ibuprofen 3 times per day for 4 days. In the experimental group a protocol was established for the application of 15 ml of Gelclair directly onto the wound 3 times per day, 1 h before meals, for 1 week.
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